M
María José Alcaraz
Researcher at Polytechnic University of Valencia
Publications - 110
Citations - 11331
María José Alcaraz is an academic researcher from Polytechnic University of Valencia. The author has contributed to research in topics: Inflammation & Heme oxygenase. The author has an hindex of 42, co-authored 108 publications receiving 7787 citations. Previous affiliations of María José Alcaraz include University of Valencia & ARCO.
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Journal ArticleDOI
Carbon Monoxide-Releasing Molecules: A Pharmacological Expedient to Counteract Inflammation
María José Alcaraz,Maria Isabel Guillén,María Luisa Ferrándiz,Javier Megías,Roberto Motterlini +4 more
TL;DR: This research will help to elucidate the molecular mechanisms underlying the pharmacological effects of CO-RMs and may lead to the development of novel therapeutic strategies for the treatment of acute and chronic inflammatory conditions.
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Heme oxygenase-1 induction modulates microsomal prostaglandin E synthase-1 expression and prostaglandin E2 production in osteoarthritic chondrocytes
Javier Megías,Maria Isabel Guillén,Victoria Clérigues,Ana I. Rojo,Antonio Cuadrado,Miguel Angel Castejón,Francisco Gomar,María José Alcaraz +7 more
TL;DR: Protecting chondrocyte viability and aggrecan content while inhibiting apoptosis and oxidative stress generation is confirmed and the potential interest of this strategy in degenerative joint diseases is suggested.
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The CO-releasing molecule CORM-3 protects against articular degradation in the K/BxN serum transfer arthritis model.
Nuria Maicas,María Luisa Ferrándiz,Isabel Devesa,Roberto Motterlini,Marije I. Koenders,Wim B. van den Berg,María José Alcaraz +6 more
TL;DR: It is shown that CORM-3 decreases the inflammatory response and protects against the degradation of cartilage and bone in the arthritic mice.
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Enhanced expression of haem oxygenase‐1 by nitric oxide and antiinflammatory drugs in NIH 3T3 fibroblasts
María José Alcaraz,Aida Habib,Marilyne Lebret,Christophe Créminon,Sylviane Levy-Toledano,Jacques Maclouf +5 more
TL;DR: Results indicate that reactive oxygen species participate in the inductive effect of NO donors or L PS on HO‐1 expression, whereas endogenous NO production may play a role in the mechanism of the synergy exhibited by SPNO and LPS on HO1 and COX‐2 expression.
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Potential role of heme oxygenase-1 in the progression of rat adjuvant arthritis
TL;DR: Rat adjuvant arthritis is an experimental model widely used to evaluate etiopathogenetic mechanisms in chronic inflammation and results support a role for heme oxygenase-1 in mediating the progression of the disease in this model of chronic arthritis.