J
Jacques Maclouf
Researcher at French Institute of Health and Medical Research
Publications - 161
Citations - 11017
Jacques Maclouf is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Platelet & Thromboxane. The author has an hindex of 57, co-authored 161 publications receiving 10836 citations. Previous affiliations of Jacques Maclouf include Anschutz Medical Campus & University of Milan.
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Journal ArticleDOI
Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators
Bart Staels,Wolfgang Koenig,Aida Habib,Régine Merval,Marilyne Lebret,Inés Pineda Torra,Inés Pineda Torra,Philippe Delerive,Philippe Delerive,Abdessamad Fadel,Abdessamad Fadel,Giulia Chinetti,Giulia Chinetti,Jean-Charles Fruchart,Jean-Charles Fruchart,Jamila Najib,Jamila Najib,Jacques Maclouf,Alain Tedgui +18 more
TL;DR: It is concluded that activators of PPARα inhibit the inflammatory response of aortic smooth-muscle cells and decrease the concentration of plasma acute-phase proteins, indicating that PPAR α in the vascular wall may influence the process of atherosclerosis and re-stenosis.
Journal Article
Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases.
Paola Patrignani,M. R. Panara,Anita Greco,Ornella Fusco,Clara Natoli,Stefano Iacobelli,Francesco Cipollone,A. Ganci,C Créminon,Jacques Maclouf +9 more
TL;DR: A model of human prostaglandin endoperoxide synthase-2 expression allowing the assessment of pharmacological inhibition in vitro and ex vivo was characterized and cyclooxygenase activity increased in parallel with the mass of a monocyte protein doublet analyzed by Western blot using antibodies directed against the carboxyl-terminal portion of human PGHS-2.
Journal ArticleDOI
Elevated levels of 8-iso-prostaglandin F2alpha in pericardial fluid of patients with heart failure: a potential role for in vivo oxidant stress in ventricular dilatation and progression to heart failure.
TL;DR: Pericardial levels of 8-iso-PGF2alpha increase with the functional severity of heart failure and are associated with ventricular dilatation, suggesting an important role for in vivo oxidant stress on ventricular remodeling and the progression to heart failure.
Journal ArticleDOI
Localization of distinct F2-isoprostanes in human atherosclerotic lesions.
Domenico Praticò,Luigi Iuliano,Alessandro Mauriello,Luigi Giusto Spagnoli,John A. Lawson,J Rokach,Jacques Maclouf,Francesco Violi,Garret A. FitzGerald +8 more
TL;DR: The results indicate that 8-epi PGF2alpha and IPF2alpha-I, two distinct F2-isoprostanes and markers of oxidative stress in vivo, are present in human atherosclerotic plaque.
Journal Article
Immunological characterization of urinary 8-epi-prostaglandin F2 alpha excretion in man.
Zhaoyue Wang,G. Ciabattoni,Christophe Créminon,John A. Lawson,Garret A. FitzGerald,Carlo Patrono,Jacques Maclouf +6 more
TL;DR: Preliminary results showed that excretion increased as a function of age, and an enzyme immunoassays and a radioimmunoassay were developed for measuring urinary concentrations of 8-epi-PGF2 alpha by raising antibodies against this compound.