M
Maria José Campagnole-Santos
Researcher at Universidade Federal de Minas Gerais
Publications - 135
Citations - 7370
Maria José Campagnole-Santos is an academic researcher from Universidade Federal de Minas Gerais. The author has contributed to research in topics: Angiotensin II & Renin–angiotensin system. The author has an hindex of 38, co-authored 130 publications receiving 6707 citations. Previous affiliations of Maria José Campagnole-Santos include National Institute of Standards and Technology & Cleveland Clinic.
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Journal ArticleDOI
Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.
Robson A.S. Santos,Ana Cristina Simões e Silva,Christine Maric,Denise M. R. Silva,Raquel Pillar Machado,Insa de Buhr,Silvia Heringer-Walther,Sérgio Veloso Brant Pinheiro,Myriam Teresa Lopes,Michael Bader,Elizabeth Pereira Mendes,Virgina Soares Lemos,Maria José Campagnole-Santos,Heinz-Peter Schultheiss,Robert C. Speth,Thomas Walther +15 more
TL;DR: Findings identify Mas as a functional receptor for Ang-(1–7) and provide a clear molecular basis for the physiological actions of this biologically active peptide.
Journal ArticleDOI
Angiotensin-(1-7): an update.
TL;DR: The evidence that Ang-(1-7) takes an important part of the mechanisms aimed to counteract the vasoconstrictor and proliferative effects of Ang II is summarized.
Journal ArticleDOI
Discovery and Characterization of Alamandine A Novel Component of the Renin–Angiotensin System
Roberto Queiroga Lautner,Daniel C. Villela,Rodrigo A. Fraga-Silva,Neiva Caldeira Silva,Thiago Verano-Braga,Fabiana P. Costa-Fraga,Joachim Jankowski,Vera Jankowski,Frederico B. De Sousa,Andréia Carvalho Alzamora,Everton Rocha Soares,Claudiane Maria Barbosa,Frank Kjeldsen,Aline C. Oliveira,Janaina F Braga,Silvia Q Savergnini,Gisele Maia,Antonio A B Peluso,Danielle G. Passos-Silva,Anderson J. Ferreira,Fabiana Alves,Almir S. Martins,Mohan K. Raizada,Renata D. Paula,Daisy Motta-Santos,Friederike Kemplin,Adriano Marçal Pimenta,Natalia Alenina,Rubén D. Sinisterra,Michael Bader,Maria José Campagnole-Santos,Robson A.S. Santos +31 more
TL;DR: Alamandine produces several physiological actions that resemble those produced by angiotensin-(1–7), including vasodilation, antifibrosis, antihypertensive, and central effects and may help to develop new therapeutic strategies for treating human cardiovascular diseases and other related disorders.
Journal ArticleDOI
Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors.
Robson A.S. Santos,Maria José Campagnole-Santos,Nilo César do Vale Baracho,Marco Antônio Peliky Fontes,Luciana Costa Silva,Liomar A.A. Neves,Djenane Ramalho de Oliveira,Sordaine M. Caligiorne,André Ricardo Vale Rodrigues,Carlos Gropen,Wania da Silva Carvalho,Ana Cristina Simões e Silva,Mahesh C. Khosla +12 more
TL;DR: Results show that A-779 is a potent and selective antagonist for Ang-(1-7), and data indicate that specific angiotensin receptors mediate the central and peripheral actions of Ang-( 1-7).
Journal ArticleDOI
Expression of an angiotensin-(1-7)-producing fusion protein produces cardioprotective effects in rats
Robson A.S. Santos,Anderson J. Ferreira,Anderson J. Ferreira,Ana Paula Nadu,Aline Nardoni Gonçalves Braga,Alvair P. Almeida,Maria José Campagnole-Santos,Ovidiu Baltatu,Radu Iliescu,Timothy L. Reudelhuber,Michael Bader +10 more
TL;DR: Transgenic rats generated that chronically overproduce ANG-(1-7) were significantly more resistant than control animals to induction of cardiac hypertrophy by isoproterenol, and transgenic rats showed a reduced duration of reperfusion arrhythmias and an improved postischemic function in isolated Langendorff heart preparations.