R
Rodrigo A. Fraga-Silva
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 68
Citations - 2763
Rodrigo A. Fraga-Silva is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Angiotensin II & Angiotensin-converting enzyme 2. The author has an hindex of 28, co-authored 65 publications receiving 2345 citations. Previous affiliations of Rodrigo A. Fraga-Silva include National Institute of Standards and Technology & Universidade Federal de Minas Gerais.
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Journal ArticleDOI
Discovery and Characterization of Alamandine A Novel Component of the Renin–Angiotensin System
Roberto Queiroga Lautner,Daniel C. Villela,Rodrigo A. Fraga-Silva,Neiva Caldeira Silva,Thiago Verano-Braga,Fabiana P. Costa-Fraga,Joachim Jankowski,Vera Jankowski,Frederico B. De Sousa,Andréia Carvalho Alzamora,Everton Rocha Soares,Claudiane Maria Barbosa,Frank Kjeldsen,Aline C. Oliveira,Janaina F Braga,Silvia Q Savergnini,Gisele Maia,Antonio A B Peluso,Danielle G. Passos-Silva,Anderson J. Ferreira,Fabiana Alves,Almir S. Martins,Mohan K. Raizada,Renata D. Paula,Daisy Motta-Santos,Friederike Kemplin,Adriano Marçal Pimenta,Natalia Alenina,Rubén D. Sinisterra,Michael Bader,Maria José Campagnole-Santos,Robson A.S. Santos +31 more
TL;DR: Alamandine produces several physiological actions that resemble those produced by angiotensin-(1–7), including vasodilation, antifibrosis, antihypertensive, and central effects and may help to develop new therapeutic strategies for treating human cardiovascular diseases and other related disorders.
Journal ArticleDOI
The Angiotensin-Converting Enzyme 2/Angiogenesis-(1–7)/Mas Axis Confers Cardiopulmonary Protection against Lung Fibrosis and Pulmonary Hypertension
Vinayak Shenoy,Anderson J. Ferreira,Yanfei Qi,Rodrigo A. Fraga-Silva,Carlos Diez-Freire,Autumn Dooies,Joo Yun Jun,Srinivas Sriramula,Nithya Mariappan,Dorna Pourang,Changaram S. Venugopal,Joseph Francis,Timothy L. Reudelhuber,Robson A.S. Santos,Jawaharlal M. Patel,Mohan K. Raizada,Michael J. Katovich +16 more
TL;DR: A cardiopulmonary protective role for the ACE2/Ang-(1-7)/Mas axis in the treatment of lung disorders is demonstrated and blockade of the Mas receptor abolished the beneficial effects of Ang-1- 7 against MCT-induced PH.
Journal ArticleDOI
Diminazene attenuates pulmonary hypertension and improves angiogenic progenitor cell functions in experimental models.
Vinayak Shenoy,Altin Gjymishka,Yagna P. R. Jarajapu,Yanfei Qi,Aqeela Afzal,Katya Rigatto,Anderson J. Ferreira,Rodrigo A. Fraga-Silva,Patrick Kearns,Jane Yellowlees Douglas,Deepmala Agarwal,Kamal K. Mubarak,Chastity Bradford,William R. Kennedy,Joo Yun Jun,Anandharajan Rathinasabapathy,Erin Bruce,Dipankar Gupta,Arturo J. Cardounel,J Mocco,Jawaharlal M. Patel,Jawaharlal M. Patel,Joseph Francis,Maria B. Grant,Michael J. Katovich,Mohan K. Raizada +25 more
TL;DR: DIZE treatment significantly prevented the development of PH in all of the animal models studied and identifies a therapeutic potential of DIZE in PH therapy.
Journal ArticleDOI
The antithrombotic effect of angiotensin-(1-7) involves mas-mediated NO release from platelets.
Rodrigo A. Fraga-Silva,Sérgio Veloso Brant Pinheiro,Andrey C. da Costa Goncalves,N. Alenina,Michael Bader,Robson A.S. Santos +5 more
TL;DR: It is shown that the antithrombotic effect of Ang-(1-7) in vivo is Mas dependent and that Mas is functionally important in hemostasis and the role of Mas in the Ang-( 1-7), which involves Mas-mediated NO release from platelets is examined.
Journal ArticleDOI
ACE2 activation promotes antithrombotic activity.
Rodrigo A. Fraga-Silva,Brian S. Sorg,Mamta Wankhede,Casey deDeugd,Joo Yun Jun,Matthew B. Baker,Yan Li,Ronald K. Castellano,Michael J. Katovich,Mohan K. Raizada,Anderson J. Ferreira,Anderson J. Ferreira +11 more
TL;DR: Results suggest that ACE2 could be a novel target for the treatment of thrombogenic diseases and attenuates thrombus formation and reduces platelet attachment to vessels.