Journal ArticleDOI
Expression of an angiotensin-(1-7)-producing fusion protein produces cardioprotective effects in rats
Robson A.S. Santos,Anderson J. Ferreira,Anderson J. Ferreira,Ana Paula Nadu,Aline Nardoni Gonçalves Braga,Alvair P. Almeida,Maria José Campagnole-Santos,Ovidiu Baltatu,Radu Iliescu,Timothy L. Reudelhuber,Michael Bader +10 more
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Transgenic rats generated that chronically overproduce ANG-(1-7) were significantly more resistant than control animals to induction of cardiac hypertrophy by isoproterenol, and transgenic rats showed a reduced duration of reperfusion arrhythmias and an improved postischemic function in isolated Langendorff heart preparations.Abstract:
Angiotensin-(1–7) [ANG-(1–7)] is a recently described heptapeptide product of the renin-angiotensin system. Because biosynthesis of ANG-(1–7) increases in animals treated with cardioprotective drug...read more
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Journal ArticleDOI
The ACE2/Angiotensin-(1–7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1–7)
Robson A.S. Santos,Walkyria O. Sampaio,Andréia Carvalho Alzamora,Daisy Motta-Santos,Natalia Alenina,Michael Bader,Maria José Campagnole-Santos +6 more
TL;DR: This review highlights the current knowledge about the roles of ANG-(1–7) in physiology and disease, with particular emphasis on the brain.
Journal ArticleDOI
Angiotensin-converting enzyme 2, angiotensin-(1-7) and Mas: new players of the renin-angiotensin system
TL;DR: Recent findings related to the biological role of the ACE2/Ang-(1-7)/Mas arm in the cardiovascular and renal systems, as well as in metabolism are discussed.
Journal ArticleDOI
ACE2, angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis
TL;DR: The role of the ACE2/Ang‐(1‐7)/Mas axis in modifying processes associated with acute and chronic inflammation, including leukocyte influx, fibrogenesis and proliferation of certain cell types is focused on.
Journal ArticleDOI
Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis.
TL;DR: This review will focus on the recent findings related to the ACE2–Ang(1–7)–Mas axis and, in particular, on its putative role as an ACE–Ang II–AT1 receptor counter‐regulatory axis within the RAS.
Journal ArticleDOI
Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters.
TL;DR: The multiple biological functions of ACE2 are discussed and it is shown that both ACE2 and its homologue Collectrin can associate with amino acid transporters and play essential role in the absorption of amino acids in the kidney and gut.
References
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Journal ArticleDOI
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Journal ArticleDOI
A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9
Mary Donoghue,Frank Y. Hsieh,Elizabeth Baronas,Kevin Godbout,Michael Gosselin,Nancy E. Stagliano,Michael J. Donovan,Betty Woolf,Keith E. Robison,Raju Jeyaseelan,Roger E. Breitbart,Susan L. Acton +11 more
TL;DR: The organ- and cell-specific expression of ACE2 and its unique cleavage of key vasoactive peptides suggest an essential role for ACE2 in the local renin-angiotensin system of the heart and kidney.
Journal ArticleDOI
Angiotensin-converting enzyme 2 is an essential regulator of heart function
Michael A. Crackower,Renu Sarao,Renu Sarao,Gavin Y. Oudit,Gavin Y. Oudit,Chana Yagil,Ivona Kozieradzki,Ivona Kozieradzki,Sam E. Scanga,Antonio J. Oliveira-dos-Santos,Joan da Costa,Liyong Zhang,York Pei,James W. Scholey,Carlos M. Ferrario,Armen S. Manoukian,Mark C. Chappell,Peter H. Backx,Peter H. Backx,Yoram Yagil,Josef M. Penninger +20 more
TL;DR: These genetic data for ACE2 show that it is an essential regulator of heart function in vivo and targeted disruption of ACE2 in mice results in a severe cardiac contractility defect, increased angiotensin II levels, and upregulation of hypoxia-induced genes in the heart.
Journal ArticleDOI
Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase.
Chad S Vickers,Paul Hales,Virendar K. Kaushik,Larry Dick,James M. Gavin,Jin Tang,Kevin Godbout,Thomas F. Parsons,Elizabeth Baronas,Frank Y. Hsieh,Susan L. Acton,Michael A. Patane,Andrew J. Nichols,Peter J. Tummino +13 more
TL;DR: The physiological role of ACE2 is elucidated, and its catalytic activity was characterized, and a consensus sequence of: Pro-X (1–3 residues)-Pro-Hydrophobic, where hydrolysis occurs between proline and the hydrophobic amino acid is revealed.
Journal ArticleDOI
Angiotensin-(1-7): an update.
TL;DR: The evidence that Ang-(1-7) takes an important part of the mechanisms aimed to counteract the vasoconstrictor and proliferative effects of Ang II is summarized.
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Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.
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