Maria Romano

TL;DR: JAM is a new component of endothelial and epithelial junctions that play a role in regulating monocyte transmigration and is identified as a novel immunoglobulin gene superfamily member that consists of two V-type Ig domains.

TL;DR: In vivo and in vitro evidence supports the concept that the IL-6 system plays an unexpected positive role in local inflammatory reactions by amplifying leukocyte recruitment.

TL;DR: In this article, Lovastatin and pravastatin were administered to mice according to a treatment schedule that significantly inhibited the hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity without affecting total blood cholesterol.

TL;DR: It is suggested that bindarit's beneficial effects in models of joint and kidney inflammation are related to its anti-MCP-1 action and it is possible to selectively and differentially regulate chemokines by targeting their production with small synthetic molecules.

TL;DR: The effect of compounds A, B and C on leukocyte recruitment was paralleled by a significant inhibition of interleukin-6 and prostaglandin E(2)production in the exudate, similarly to indomethacin, and by a partial reduction of vascular permeability, which may be relevant for the design and development of innovative anti-inflammatory molecules among the 4H-triazolo-5-amine derivatives.