Maria Teresa Guagnano

TL;DR: Android obesity is associated with enhanced lipid peroxidation and persistent platelet activation and these abnormalities are driven by inflammatory triggers related to the degree of abdominal adiposity and are, at least in part, reversible with a successful weight-loss program.

TL;DR: The complex interactions between platelets and the pathogenic events occurring in obesity and MS are addressed, trying to translate this body of mechanistic information into a clinically relevant read‐out, in order to establish novel strategies in the prevention/treatment of atherothrombosis.

TL;DR: The results are the first to document an in vivo relationship between insulin sensitivity and coagulative activation in obesity and the elevated TGF-beta 1 levels detected in the obese population may provide a biochemical link between insulin resistance and an increased risk for cardiovascular disease.

TL;DR: In hyperthyroid patients, the increased lipid peroxidation was strictly related to free thyroxine levels, whereas in hypothyroidism it was strongly influenced by serum lipids.

TL;DR: Insulin resistance is a major determinant of platelet activation in female obesity, independently of adiponectin, CRP, CD40L, and lipid patterns.