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Nancy Ann Hosken
Researcher at University of Washington
Publications - 27
Citations - 5296
Nancy Ann Hosken is an academic researcher from University of Washington. The author has contributed to research in topics: Cytotoxic T cell & Antigen. The author has an hindex of 15, co-authored 25 publications receiving 5108 citations. Previous affiliations of Nancy Ann Hosken include Corixa Corporation & Fred Hutchinson Cancer Research Center.
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Journal Article
Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.
Steven E. Macatonia,Nancy Ann Hosken,Mark J. Litton,Pedro L. Vieira,Chyi-Song Hsieh,J. A. Culpepper,Maria Wysocka,Giorgio Trinchieri,Kenneth M. Murphy,Anne O'Garra +9 more
TL;DR: In addition to inducing proliferation and clonal expansion of naive T cells, dendritic cells, by their production of IL-12, play a direct role in the development of IFN-gamma-producing cells that are important for cell-mediated immune responses.
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Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects
Andrew W. Sylwester,Bridget L. Mitchell,John B. Edgar,Cara Taormina,Christian Pelte,Franziska Ruchti,Paul R. Sleath,Kenneth H. Grabstein,Nancy Ann Hosken,Florian Kern,Jay A. Nelson,Louis J. Picker +11 more
TL;DR: The first glimpse of the total human T cell response to a complex infectious agent is provided and insight into the rules governing immunodominance and cross-reactivity in complex viral infections of humans is provided.
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The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.
TL;DR: It is shown that the antigen dose used in primary cultures could directly affect Th phenotype development from naive DO11.10 TCR-alpha beta-transgenic CD4+ T cells when dendritic cells or activated B cells were used as the antigen- presenting cells.
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Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations.
Peter J. M. Openshaw,Erin Murphy,Nancy Ann Hosken,Vernon C. Maino,Kenneth A. Davis,Kenneth M. Murphy,Anne O'Garra +6 more
TL;DR: Results show that stimulation in the presence of polarizing stimuli results in cells producing either IFN-gamma or IL-4, but that coproduction can occur in rare cells under defined conditions.
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Reversibility of T helper 1 and 2 populations is lost after long-term stimulation.
Erin Murphy,Kazuko Shibuya,Nancy Ann Hosken,Peter J. M. Openshaw,Maino,K Davis,Kenneth M. Murphy,Anne O'Garra +7 more
TL;DR: It is shown that strongly polarized Th1 and Th2 populations assessed by immunoassay are heterogeneous using flow cytometry to detect single cells producing interferon gamma (IFN-gamma) and interleukin 4 (IL-4), which may explain previous reports that Th1 cells can be converted to Th2 cells.