Mariana Lima Vale

TL;DR: The results suggest that the nociceptive activity of zymosan and acetic acid in the writhing model is due to the release of TNF-alpha, interleukin 1beta and interleucin 8 by resident peritoneal macrophages and mast cells.

TL;DR: Results suggest that nitric oxide and peroxynitrite are also involved in the neurotoxic effect of oxaliplatin and that rutin and quercetin can inhibit their effect in the spinal cord.

TL;DR: The results demonstrate that IL-4, -10, and -13 display analgesic activity that is probably not due to endogenous opioid release, and could be related to a peripheral mechanism, probably via the inhibition of the release of the pro-inflammatory cytokines TNF-α and IL-1β by resident peritoneal macrophages.

TL;DR: The demonstration that thalidomide is able to inhibit inflammatory hyperalgesia in rats and the writhing nociceptive response in mice suggests that these analgesic effects seem to be a consequence of the inhibition of TNF-alpha production, and indicates the need for investigations on the possibility of the use of thalidumide for the treatment of pain refractory to classical non-narcotic analgesics.

TL;DR: Results give further evidences for a neuroprogressive etiology and course of schizophrenia and that clozapine may partly alleviate this process.