Journal ArticleDOI
Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice
Ronaldo A. Ribeiro,Mariana Lima Vale,Sara M. Thomazzi,Adriana Balbina Paoliello Paschoalato,Steve Poole,S. H. Ferreira,Fernando Q. Cunha +6 more
TLDR
The results suggest that the nociceptive activity of zymosan and acetic acid in the writhing model is due to the release of TNF-alpha, interleukin 1beta and interleucin 8 by resident peritoneal macrophages and mast cells.About:
This article is published in European Journal of Pharmacology.The article was published on 2000-11-03. It has received 571 citations till now. The article focuses on the topics: Zymosan & Interleukin.read more
Citations
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Role of the immune system in chronic pain
TL;DR: This work has shown that immune cell products might have a crucial role not just in inflammatory pain, but also in neuropathic pain caused by damage to peripheral nerves or to the CNS.
Journal ArticleDOI
A cascade of cytokines mediates mechanical inflammatory hypernociception in mice.
Thiago M. Cunha,Waldiceu A. Verri,João Santana da Silva,Stephen Poole,Fernando Q. Cunha,Sindynara Ferreira +5 more
TL;DR: Results extend to mice the concept that the release of primary mediators responsible for hypernociception is preceded by a cascade of cytokines.
Journal ArticleDOI
Hypernociceptive role of cytokines and chemokines: targets for analgesic drug development?
Waldiceu A. Verri,Thiago M. Cunha,Carlos Amílcar Parada,Stephen Poole,Fernando Q. Cunha,Sérgio H. Ferreira +5 more
TL;DR: The evidence suggesting pro- and anti-inflammatory cytokines and chemokines are potential targets to develop novel drugs and therapies for the treatment of pain is emphasized, emphasizing the importance of the direct and indirect actions of cytokine actions in inflammatory and neuropathic hypernociception.
Journal ArticleDOI
Acute p38-Mediated Modulation of Tetrodotoxin-Resistant Sodium Channels in Mouse Sensory Neurons by Tumor Necrosis Factor-α
Xiaochun Jin,Robert W. Gereau +1 more
TL;DR: The results suggest that TNFα may induce acute peripheral mechanical sensitization by acting directly on TNFR1 in primary afferent neurons, resulting in p38-dependent modulation of TTX-resistant Na+ channels.
Journal ArticleDOI
FODMAPs alter symptoms and the metabolome of patients with IBS: a randomised controlled trial
K. McIntosh,K. McIntosh,David E. Reed,Theresa Schneider,Frances Dang,Ammar Hassanzadeh Keshteli,Giada De Palma,Karen L. Madsen,Premysl Bercik,Stephen J. Vanner +9 more
TL;DR: IBS symptoms are linked to FODMAP content and associated with alterations in the metabolome, and in subsets of patients, FOD MAPs modulate histamine levels and the microbiota, both of which could alter symptoms.
References
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Journal ArticleDOI
Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1
Charles A. Dinarello,Joseph G. Cannon,Sheldon M. Wolff,H A Bernheim,Bruce Beutler,Anthony Cerami,Irene S. Figari,Michael A. Palladino,O'connor John +8 more
TL;DR: These studies show that TNF (cachectin) is another endogenous pyrogen which, like IL-1 and IFN-alpha, directly stimulate hypothalamic PGE2 synthesis and is an endogenous inducer ofIL-1.
Journal ArticleDOI
Studies on the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine.
Journal ArticleDOI
The abdominal constriction response and its suppression by analgesic drugs in the mouse
Journal ArticleDOI
Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha
TL;DR: It is reported here that mast cells, which are selectively located at portals of bacterial entry, are important to host defence against bacterial infections.
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