M
Marie-Christine Bouton
Researcher at French Institute of Health and Medical Research
Publications - 54
Citations - 1140
Marie-Christine Bouton is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Thrombin & Serpin. The author has an hindex of 20, co-authored 49 publications receiving 958 citations. Previous affiliations of Marie-Christine Bouton include University of Paris & Sorbonne.
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Journal ArticleDOI
Protease Nexin-1 Inhibits Plasminogen Activation-induced Apoptosis of Adherent Cells *
Patrick Rossignol,Benoît Ho-Tin-Noé,Roger Vranckx,Marie-Christine Bouton,Olivier Meilhac,H. Roger Lijnen,Marie-Claude Guillin,Jean-Baptiste Michel,Eduardo Anglés-Cano +8 more
TL;DR: Protease nexin-1 may be an important anti-apoptotic factor for adherent cells and could be a useful tool to evaluate therapeutic agents such as serpins in vascular pathologies involving pericellular protease-protease inhibitor imbalance.
Journal ArticleDOI
Emerging role of serpinE2/protease nexin-1 in hemostasis and vascular biology.
Marie-Christine Bouton,Marie-Christine Bouton,Yacine Boulaftali,Yacine Boulaftali,Benjamin Richard,Benjamin Richard,Véronique Arocas,Véronique Arocas,Jean-Baptiste Michel,Jean-Baptiste Michel,Martine Jandrot-Perrus,Martine Jandrot-Perrus +11 more
TL;DR: Recent data underlining the emerging role of PN-1 as a key factor in the responses of vessels to injury are reviewed, providing insights that may allow the development of drugs and treatment strategies to prevent or limit thrombotic disorders.
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Critical role of neutrophil extracellular traps (NETs) in patients with Behcet's disease.
Alexandre Le Joncour,Raphael Martos,Stéphane Loyau,Nicolas Lelay,Antoine Dossier,Aurélie Cazes,Pierre Fouret,Fanny Domont,Thomas Papo,Martine Jandrot-Perrus,Marie-Christine Bouton,Patrice Cacoub,Nadine Ajzenberg,David Saadoun,Yacine Boulaftali +14 more
TL;DR: Targeting NETs may represent a potential therapeutic target for the reduction or prevention of BD-associated thrombotic risk and contribute to the procoagulant state.
Journal ArticleDOI
Platelet Protease Nexin-1, a Serpin That Strongly Influences Fibrinolysis and Thrombolysis
Yacine Boulaftali,Benoît Ho-Tin-Noé,Ana Pena,Stéphane Loyau,Laurence Venisse,Déborah François,Benjamin Richard,Véronique Arocas,Jean-Philippe Collet,Martine Jandrot-Perrus,Marie-Christine Bouton +10 more
TL;DR: Inhibition of PN-1 is predicted to promote endogenous and exogenous tissue plasminogen activator–mediated fibrinolysis and may enhance the therapeutic efficacy of thrombolytic agents.
Journal ArticleDOI
Anticoagulant and antithrombotic properties of platelet protease nexin-1
Yacine Boulaftali,Frédéric Adam,Laurence Venisse,Véronique Ollivier,Benjamin Richard,Sabrina Taieb,Denis Monard,Rémi Favier,Marie-Christine Alessi,Marijke Bryckaert,Véronique Arocas,Martine Jandrot-Perrus,Marie-Christine Bouton +12 more
TL;DR: Thrombus formation, induced ex vivo by collagen in blood flow conditions and in vivo by FeCl(3)-induced injury, is significantly increased in PN-1-deficient mice, demonstrating the antithrombotic properties of platelet PN1.