Journal ArticleDOI
Anticoagulant and antithrombotic properties of platelet protease nexin-1
Yacine Boulaftali,Frédéric Adam,Laurence Venisse,Véronique Ollivier,Benjamin Richard,Sabrina Taieb,Denis Monard,Rémi Favier,Marie-Christine Alessi,Marijke Bryckaert,Véronique Arocas,Martine Jandrot-Perrus,Marie-Christine Bouton +12 more
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TLDR
Thrombus formation, induced ex vivo by collagen in blood flow conditions and in vivo by FeCl(3)-induced injury, is significantly increased in PN-1-deficient mice, demonstrating the antithrombotic properties of platelet PN1.About:
This article is published in Blood.The article was published on 2010-01-07. It has received 71 citations till now. The article focuses on the topics: Gray platelet syndrome & Platelet factor 4.read more
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Platelets, inflammation and tissue regeneration
TL;DR: They are major players in atherosclerosis and related diseases, pathologies of the central nervous system (Alzheimers disease, multiple sclerosis), cancer and tumour growth, and participate in other tissue-related acquired pathologies such as skin diseases and allergy, rheumatoid arthritis, liver disease; while, paradoxically, autologous platelet-rich plasma and platelet releasate are being used as an aid to promote tissue repair and cellular growth.
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Pharmacology of Heparin and Related Drugs
TL;DR: A “state of the art” review of the current understanding of the pharmacology of heparin and related drugs and an overview of the status of development of such drugs are provided.
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How platelets safeguard vascular integrity
TL;DR: It is proposed that modulating these newly described platelet functions may help treat haemorrhage as well as treat cancer by increasing the efficacy of drug delivery to tumours.
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Thrombin and Collagen Induce a Feedback Inhibitory Signaling Pathway in Platelets Involving Dissociation of the Catalytic Subunit of Protein Kinase A from an NFκB-IκB Complex
Stepan Gambaryan,Anna Kobsar,Natalia Rukoyatkina,Natalia Rukoyatkina,Sabine Herterich,Joerg Geiger,Albert Smolenski,Suzanne M. Lohmann,Ulrich Walter +8 more
TL;DR: It is concluded that thrombin and collagen not only cause platelet activation but also appear to fine-tune this response by initiating downstream NFκB-dependent PKAc activation, as a novel feedback inhibitory signaling mechanism for preventing undesired plateletactivation.
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Radiolabeled Fucoidan as a P-Selectin Targeting Agent for In Vivo Imaging of Platelet-Rich Thrombus and Endothelial Activation
François Rouzet,Laure Bachelet-Violette,Jean-Marc Alsac,Michimasa Suzuki,Alain Meulemans,Liliane Louedec,Anne Petiet,Martine Jandrot-Perrus,Frédéric Chaubet,Jean-Baptiste Michel,Dominique Le Guludec,Didier Letourneur +11 more
TL;DR: 99mTc-fucoidan is supported as a relevant imaging agent for in vivo detection of biologic activities associated with P-selectin overexpression, such as arterial thrombus and ischemic memory.
References
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Surface-dependent reactions of the vitamin K-dependent enzyme complexes
TL;DR: It is concluded that factor VII is most likely a zymogen, just as are the other proenzymes of the blood clotting process, and the kinetic constants obtained for the various coagulation reactions determined in vitro provide some insights into how these pathways may function in vivo.
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Platelets and Thrombin Generation
TL;DR: Examination of evidence that platelets play a major role in localizing and controlling the burst of thrombin generation leading to fibrin clot formation concludes that changes in lipid composition are necessary but not sufficient to account for platelet surface regulation of thROMbin generation.
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Measurement of plasminogen activator inhibitor 1 in biologic fluids with a murine monoclonal antibody-based enzyme-linked immunosorbent assay.
Paul Declerck,Marie-Christine Alessi,M Verstreken,Egbert K. O. Kruithof,Irène Juhan-Vague,Desire Collen +5 more
TL;DR: The present assay, based on stable and reproducible reagents, allows the specific determination of PAI-1 antigen in biologic fluids and may facilitate interlaboratory comparisons and be useful for further investigations of the role of PAi-1 in clinical conditions associated with impaired fibrinolysis and/or a tendency to thrombosis.
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Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization.
Peter Carmeliet,Lena Kieckens,Luc Schoonjans,Beverly Ream,A van Nuffelen,George C. Prendergast,M Cole,Roderick T. Bronson,D. Collen,Richard C. Mulligan +9 more
TL;DR: Homozygous plasminogen activator inhibitor-1 (PAI-1)-deficient mice were generated by homologous recombination in D3 embryonic stem cells and showed no apparent macroscopic or microscopic histological abnormalities.
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Thrombin generation in plasma: its assessment via the endogenous thrombin potential.
TL;DR: The ETP is developed and suggested that it is a sensitive indicator for every form of anticoagulation and can be designed to indicate deficiencies in protein C and S and APC (activated protein C) resistance.