M
Marie-Christine Vaney
Researcher at Pasteur Institute
Publications - 32
Citations - 3196
Marie-Christine Vaney is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Lipid bilayer fusion & Virus. The author has an hindex of 19, co-authored 29 publications receiving 2863 citations. Previous affiliations of Marie-Christine Vaney include Centre national de la recherche scientifique & Institut national de la recherche agronomique.
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Journal ArticleDOI
Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak
Isabelle Schuffenecker,Isabelle Iteman,Alain Michault,Séverine Murri,Lionel Frangeul,Marie-Christine Vaney,Marie-Christine Vaney,Rachel Lavenir,Nathalie Pardigon,Jean-Marc Reynes,François Pettinelli,Leon Biscornet,Laure Diancourt,Stéphanie Michel,Stéphane Duquerroy,Stéphane Duquerroy,Stéphane Duquerroy,Ghislaine Guigon,Marie-Pascale Frenkiel,Anne-Claire Brehin,Nadège Cubito,Philippe Desprès,Frank Kunst,Félix A. Rey,Félix A. Rey,Hervé Zeller,Sylvain Brisse +26 more
TL;DR: The results indicate that the chikungunya virus outbreak was initiated by a strain related to East-African isolates, from which viral variants have evolved following a traceable microevolution history and may be due to adaptation to the mosquito vector.
Journal ArticleDOI
Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography
James E. Voss,Marie-Christine Vaney,Marie-Christine Vaney,Stéphane Duquerroy,Stéphane Duquerroy,Stéphane Duquerroy,Clemens Vonrhein,Christine Girard-Blanc,Christine Girard-Blanc,Elodie Crublet,Elodie Crublet,Andrew J. Thompson,Gérard Bricogne,Félix A. Rey,Félix A. Rey +14 more
TL;DR: The crystal structures of the precursor p62–E1 heterodimer and of the mature E3–E2– E1 glycoprotein complexes are reported and provide new insight into the acid-triggered conformational change on the virus particle and its inbuilt inhibition mechanism in the immature complex.
Journal ArticleDOI
Recognition determinants of broadly neutralizing human antibodies against dengue viruses
Alexander Rouvinski,Alexander Rouvinski,Pablo Guardado-Calvo,Pablo Guardado-Calvo,Giovanna Barba-Spaeth,Giovanna Barba-Spaeth,Stéphane Duquerroy,Stéphane Duquerroy,Stéphane Duquerroy,Marie-Christine Vaney,Marie-Christine Vaney,Carlos M. Kikuti,Carlos M. Kikuti,M. Erika Navarro Sanchez,M. Erika Navarro Sanchez,Wanwisa Dejnirattisai,Wiyada Wongwiwat,Ahmed Haouz,Christine Girard-Blanc,Stéphane Petres,William Shepard,Philippe Desprès,Fernando Arenzana-Seisdedos,Philippe Dussart,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Gavin R. Screaton,Félix A. Rey,Félix A. Rey +28 more
TL;DR: X-ray structures of four broadly neutralizing antibodies in complex with the envelope glycoprotein E from dengue virus serotype 2 are described, revealing that the recognition determinants are at a serotype-invariant site at the E-dimer interface, including the exposed main chain of the E fusion loop and the two conserved glycan chains.
Journal ArticleDOI
The bright and the dark side of human antibody responses to flaviviruses: lessons for vaccine design
Félix A. Rey,Félix A. Rey,Karin Stiasny,Marie-Christine Vaney,Marie-Christine Vaney,Mariano Dellarole,Mariano Dellarole,Franz X. Heinz +7 more
TL;DR: This review analyzes the molecular determinants of the dual antibody response to flavivirus infection or vaccination in humans and highlights the role of conserved partially cryptic epitopes giving rise to cross‐reacting and poorly neutralizing, ADE‐prone antibodies.
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Structure and Interactions at the Viral Surface of the Envelope Protein E1 of Semliki Forest Virus
TL;DR: The crystal structure of monomeric E1 refined to 3 A resolution is reported and the amino acids involved in contacts in the virion are described and open the way to rational mutagenesis approaches to shed light on SFV assembly.