Nathalie Pardigon

TL;DR: The results indicate that the chikungunya virus outbreak was initiated by a strain related to East-African isolates, from which viral variants have evolved following a traceable microevolution history and may be due to adaptation to the mosquito vector.

TL;DR: Sequencing of the 5' terminal region from single molecules cloned into pBR327 revealed that these primers are rich in C and G residues and possess a U or a C adjacent to the viral sequence.

TL;DR: An assay to infect mouse E15 embryonic brain slices with ZIKV, WNV and dengue virus serotype 4 (DENV-4) is described and it is shown that this tissue is able to support viral replication of ZikV and WNV, but not DENV- 4.

TL;DR: It is demonstrated that diverse RNA viruses rely on the polyamine pathway for replication and polyamine biosynthesis as a promising drug target, as well as its potential as a target in the development of further antivirals or currently available molecules.

TL;DR: The findings shed new light on a molecular mechanism used by dengue viruses during the late stages of the life cycle and demonstrate a novel function for class II Arf proteins.