Showing papers by "Marie-Claire Chapuy published in 1984"
TL;DR: Serum BGP appears to be a specific marker for bone formation and can predict the histological profile in PMO and should be valuable in assessing the effects of treatments that increase bone formation.
666 citations
Journal Article•
88 citations
Journal Article•
TL;DR: Four patients under maintenance dialysis for chronic renal failure were suffering from aluminium toxicity, one showed evidence of encephalopathy, two presented with fractures and one was asymptomatic, thus confirming the diagnosis of aluminium overload.
Abstract: Four patients under maintenance dialysis for chronic renal failure were suffering from aluminium toxicity. One showed evidence of encephalopathy, two presented with fractures and one was asymptomatic. Hypercalcaemia was constant, whereas high serum aluminium levels were present in only 2 patients. In all cases, iliac bone biopsy specimens, non-decalcified and stained with Aluminium , were found to contain aluminium deposits along the mineralization fronts, thus confirming the diagnosis of aluminium overload. In addition, biopsies revealed an excess of osteoid tissue with morphological and dynamic signs of osteomalacia (2 cases) or strongly depressed bone formation (2 cases). Histomorphometric bone biopsy appears to be the best mean of diagnosing aluminium intoxication and analyzing its effects on bone remodeling and mineralization. It is also very useful to monitor the treatment.
5 citations