Marie-France Berthault

TL;DR: The essential role of mTOR/S6K1 in orchestrating β-cell adaptation to hyperglycemia in type 2 diabetes is emphasized and it is likely that treatments based on mTOR inhibition will cause exacerbation of diabetes.

TL;DR: The data show that glucose and insulin may have specific stimulating effects on beta-cell growth and function in vivo in adult rats independently of the influence they exert each other on their respective plasma concentration.

TL;DR: Surgical denervation of the white fat pad does not alter the glucose and lipid metabolisms, and by contrast, it accelerated adipocyte differentiation and led to the recruitment of new precursors.

TL;DR: The data show that lipid infusion provokes beta-cell hyperresponsiveness in vivo, at least in part through changes in alpha2-adrenergic innervation.

TL;DR: The study indicates that the long-range deteriorating effects on glucose homeostasis of gestationai hyperglycemia in the F1generation are transmitted to the F2 generation and suggests that a perturbed fetal metabolic environment contributes to the inheritance of diabetes mellitus.