M
Marie Wishart
Researcher at Wellcome Trust Centre for Human Genetics
Publications - 4
Citations - 583
Marie Wishart is an academic researcher from Wellcome Trust Centre for Human Genetics. The author has contributed to research in topics: Maturity onset diabetes of the young & Population. The author has an hindex of 3, co-authored 4 publications receiving 577 citations.
Papers
More filters
Journal ArticleDOI
A Genomewide Scan for Loci Predisposing to Type 2 Diabetes in a U.K. Population (The Diabetes UK Warren 2 Repository): Analysis of 573 Pedigrees Provides Independent Replication of a Susceptibility Locus on Chromosome 1q
Steven Wiltshire,Steven Wiltshire,Andrew T. Hattersley,Graham A. Hitman,Mark Walker,Jonathan C. Levy,Mike Sampson,Stephen O'Rahilly,Timothy M. Frayling,John I. Bell,John I. Bell,G. Mark Lathrop,Amanda J. Bennett,Amanda J. Bennett,Ranjit Dhillon,Christopher Fletcher,C J Groves,Elizabeth C. Jones,Philip Prestwich,Nikol Simecek,Pamidighantam V. Subba Rao,Marie Wishart,Richard Foxon,Simon L. Howell,Damian Smedley,Lon R. Cardon,Stephan Menzel,Mark I. McCarthy +27 more
TL;DR: These data, derived from one of the largest genome scans undertaken in this condition, confirm that individual susceptibility-gene effects for type 2 diabetes are likely to be modest in size and should accelerate positional cloning efforts in these regions of interest.
Journal ArticleDOI
Studies of Association between the Gene for Calpain-10 and Type 2 Diabetes Mellitus in the United Kingdom.
Julie Evans,Timothy M. Frayling,Paul G. Cassell,P J Saker,Graham A. Hitman,Mark Walker,Jonathan C. Levy,Stephen O'Rahilly,Pamidighantam V. Subba Rao,Amanda J. Bennett,Elizabeth C. Jones,Stephan Menzel,Philip Prestwich,Nikol Simecek,Marie Wishart,Ranjit Dhillon,Christopher Fletcher,Ann Millward,Andrew G. Demaine,Terence J. Wilkin,Yukio Horikawa,Nancy J. Cox,Graeme I. Bell,Sian Ellard,Mark I. McCarthy,Mark I. McCarthy,Andrew T. Hattersley +26 more
TL;DR: In conclusion, it is suggested that other alleles at this locus may increase type 2 diabetes risk in the U.K. population.
Journal ArticleDOI
A Genome-Wide Scan in Families With Maturity-Onset Diabetes of the Young: Evidence for Further Genetic Heterogeneity
Timothy M. Frayling,Cecilia M. Lindgren,Jean Claude Chevre,Stephan Menzel,Marie Wishart,Yamina Benmezroua,Alison Brown,Julie Evans,Pamidghantam Subba Rao,Christian Dina,Cécile Lecoeur,Timo Kanninen,Peter Almgren,Michael P. Bulman,Youxiang Wang,James L. Mills,R Wright-Pascoe,Melanie M. Mahtani,Francesco Prisco,Angels Costa,Ignacio Cognet,Torben Hansen,Oluf Pedersen,Sian Ellard,Tiinamaija Tuomi,Leif Groop,Philippe Froguel,Andrew T. Hattersley,Martine Vaxillaire +28 more
TL;DR: This work combined the results from three genome-wide scans on a total of 23 families fitting MODY criteria to facilitate the identification of novel MODY loci, using both a strict parametric model of inheritance with heterogeneity and a model-free analysis.
Journal Article
A genome scan reveals heterogeneity among European families with maturity onset diabetes of the young
Timothy M. Frayling,Stephan Menzel,Marie Wishart,M Vaxillaire,Cecilia M. Lindgren,Tiinamaija Tuomi,Y Wang,Andrew A. Brown,M. P. Bulman,Sian Ellard,Julie Evans,Rao Pvs.,James L. Mills,C.J.J. Tack,Christian Dina,Philippe Froguel,Leif Groop,Melanie M. Mahtani,Andrew T. Hattersley +18 more