M
Mariko Hara-Chikuma
Researcher at Keio University
Publications - 41
Citations - 4352
Mariko Hara-Chikuma is an academic researcher from Keio University. The author has contributed to research in topics: Aquaporin 3 & Glycerol transport. The author has an hindex of 25, co-authored 36 publications receiving 3833 citations. Previous affiliations of Mariko Hara-Chikuma include Kyoto University & University of California, San Francisco.
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Journal ArticleDOI
Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption
TL;DR: A fundamental role of water channels in cell migration, which is central to diverse biological phenomena including angiogenesis, wound healing, tumour spread and organ regeneration, is supported.
Journal ArticleDOI
Aquaporins—new players in cancer biology
Alan S. Verkman,Mariko Hara-Chikuma,Mariko Hara-Chikuma,Marios C. Papadopoulos,Marios C. Papadopoulos +4 more
TL;DR: The data suggest that AQP expression in tumor cells and tumor vessels facilitates tumor growth and spread, suggesting AQP inhibition as a novel antitumor therapy.
Journal ArticleDOI
Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing
TL;DR: In this paper, the water/glycerol-transporting protein aquaporin-3 (AQP3) was shown to be involved in epidermal cell migration and proliferation.
Journal ArticleDOI
Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulation.
Mariko Hara-Chikuma,Eisei Sohara,Tatemitsu Rai,Masahito Ikawa,Masaru Okabe,Sei Sasaki,Shinichi Uchida,Alan S. Verkman +7 more
TL;DR: The data suggest that adipocyte hypertrophy in AQP7 deficiency results from defective glycerol exit and consequent accumulation of glycersol and triglycerides, which may reduce adipocyte volume and fat mass in obesity.
Journal ArticleDOI
Disruption of Aquaporin-11 Produces Polycystic Kidneys following Vacuolization of the Proximal Tubule
Yoshiyuki Morishita,Toshiyuki Matsuzaki,Mariko Hara-Chikuma,Ayaka Andoo,Mariko Shimono,Asako Matsuki,Katsuki Kobayashi,Masahiro Ikeda,Tadashi Yamamoto,Alan S. Verkman,Eiji Kusano,Shigeo Ookawara,Kuniaki Takata,Sei Sasaki,Kenichi Ishibashi +14 more
TL;DR: Data demonstrate that AQP11 is essential for the proximal tubular function and will provide a new mechanism for cystogenesis in polycystic kidney diseases.