M
Marina E Anderson
Researcher at University of Liverpool
Publications - 40
Citations - 2468
Marina E Anderson is an academic researcher from University of Liverpool. The author has contributed to research in topics: Placebo & Randomized controlled trial. The author has an hindex of 23, co-authored 37 publications receiving 1987 citations. Previous affiliations of Marina E Anderson include University of Manchester & Lancaster University.
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Journal ArticleDOI
Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial
Dinesh Khanna,Christopher P. Denton,Angelika Jahreis,Jacob M van Laar,Tracy M. Frech,Marina E Anderson,Murray Baron,Lorinda Chung,Gerhard Fierlbeck,Santhanam Lakshminarayanan,Yannick Allanore,Janet E. Pope,Gabriela Riemekasten,Virginia D. Steen,Ulf Müller-Ladner,Robert Lafyatis,Giuseppina Stifano,Helen Spotswood,Haiyin Chen-Harris,Sebastian Dziadek,Alyssa Morimoto,Thierry Sornasse,Jeffrey Siegel,Daniel E. Furst +23 more
TL;DR: Tocilizumab was not associated with a significant reduction in skin thickening and should be investigated in a phase 3 trial before definitive conclusions can be made about its risks and benefits.
Journal ArticleDOI
The many faces of interleukin-6: the role of IL-6 in inflammation, vasculopathy, and fibrosis in systemic sclerosis.
TL;DR: The biology of interleukin-6 is reviewed, the existing evidence that interventions designed to block interleucin- 6 signalling are of therapeutic relevance in SSc is evaluated, and the evidence for interleuko-6 dysregulation in S sc is explored.
Journal ArticleDOI
Safety and efficacy of subcutaneous tocilizumab in systemic sclerosis: results from the open-label period of a phase II randomised controlled trial (faSScinate)
Dinesh Khanna,Christopher P. Denton,Celia J. F. Lin,Jacob M van Laar,Tracy M. Frech,Marina E Anderson,Murray Baron,Lorinda Chung,Gerhard Fierlbeck,Santhanam Lakshminarayanan,Yannick Allanore,Janet E. Pope,Gabriela Riemekasten,Virginia D. Steen,Ulf Müller-Ladner,Helen Spotswood,Laura Burke,Jeffrey Siegel,Angelika Jahreis,Daniel E. Furst +19 more
TL;DR: Skin score improvement and FVC stabilisation in the double-blind period were observed in placebo-treated patients who transitioned to tocilizumab and were maintained in the open-label period and safety data indicated increased serious infections in patients with SSc but no new safety signals with tocilIZumab.
Journal ArticleDOI
Seventeen-point dermal ultrasound scoring system—a reliable measure of skin thickness in patients with systemic sclerosis
TL;DR: The results suggest that the 17-point dermal ultrasound scoring system is extremely reliable and may therefore be a useful measure of outcome, including in clinical trials.
Journal Article
Computerized nailfold video capillaroscopy--a new tool for assessment of Raynaud's phenomenon.
Marina E Anderson,P Danny Allen,Tonia Moore,Val Hillier,Christopher J. Taylor,Ariane L. Herrick +5 more
TL;DR: The key feature of the newly developed system is that it improves reproducibility of nailfold capillary measurements by allowing reidentification of the same capillaries by different observers, and has the potential of being a valuable outcome measure of microvessel disease/involvement in clinical trials of scleroderma spectrum disorders.