M
Marina Pretolani
Researcher at University of Paris
Publications - 19
Citations - 1442
Marina Pretolani is an academic researcher from University of Paris. The author has contributed to research in topics: Proinflammatory cytokine & Lung. The author has an hindex of 12, co-authored 19 publications receiving 1300 citations. Previous affiliations of Marina Pretolani include French Institute of Health and Medical Research & Sorbonne.
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Journal ArticleDOI
A Chitinase-like Protein in the Lung and Circulation of Patients with Severe Asthma
Geoffrey L. Chupp,Chun Geun Lee,Nizar N. Jarjour,Yun M. Shim,Carole Holm,Susan He,James Dziura,Jennifer L. Reed,Anthony J. Coyle,Peter A. Kiener,Mark R. Cullen,Martine Grandsaigne,Marie-Christine Dombret,Michel Aubier,Marina Pretolani,Jack A. Elias +15 more
TL;DR: YKL-40 is found in increased quantities in the serum and lungs in a subgroup of patients with asthma, in whom expression of chitinase in both compartments correlates with the severity of asthma.
Journal ArticleDOI
Expression of High-Mobility Group Box 1 and of Receptor for Advanced Glycation End Products in Chronic Obstructive Pulmonary Disease
Nassima Ferhani,Séverine Létuvé,Alexander Kozhich,Olivier Thibaudeau,Martine Grandsaigne,Marielle Maret,Marie-Christine Dombret,Gary P. Sims,Roland Kolbeck,Anthony J. Coyle,Michel Aubier,Marina Pretolani +11 more
TL;DR: Elevated HMGB1 expression in COPD airways may sustain inflammation and remodeling through its interaction with IL-1beta and RAGE.
Journal ArticleDOI
YKL-40 is elevated in patients with chronic obstructive pulmonary disease and activates alveolar macrophages.
Séverine Létuvé,Alexander Kozhich,Nassim Arouche,Nassim Arouche,Martine Grandsaigne,Martine Grandsaigne,Jennifer L. Reed,Marie-Christine Dombret,Peter A. Kiener,Michel Aubier,Anthony J. Coyle,Marina Pretolani,Marina Pretolani +12 more
TL;DR: It is concluded that YKL-40 is up-regulated in COPD, in which it may contribute to tissue inflammation and remodeling by sustaining the synthesis of proinflammatory and fibrogenic chemokines and of metalloproteinases by alveolar macrophages.
Journal ArticleDOI
Mouse Mast Cell Protease-4 Deteriorates Renal Function by Contributing to Inflammation and Fibrosis in Immune Complex-Mediated Glomerulonephritis
Lisa Scandiuzzi,Walid Beghdadi,Walid Beghdadi,Eric Daugas,Eric Daugas,Magnus Åbrink,Neeraj Tiwari,Neeraj Tiwari,Cristiana Brochetta,Cristiana Brochetta,Julien Claver,Julien Claver,Nassim Arouche,Nassim Arouche,Xingxing Zang,Marina Pretolani,Marina Pretolani,Renato C. Monteiro,Renato C. Monteiro,Gunnar Pejler,Ulrich Blank,Ulrich Blank +21 more
TL;DR: It is concluded that mMCP-4 chymase, contrary to the global anti-inflammatory action of mast cells, aggravates GN by promoting kidney inflammation and is suggested to represent a novel therapeutic target in GN.
Journal ArticleDOI
Lung Chitinolytic Activity and Chitotriosidase Are Elevated in Chronic Obstructive Pulmonary Disease and Contribute to Lung Inflammation
Séverine Létuvé,Alexander Kozhich,Alison A. Humbles,Yambasu A. Brewah,Marie-Christine Dombret,Martine Grandsaigne,Martine Grandsaigne,Homa Adle,Roland Kolbeck,Michel Aubier,Anthony J. Coyle,Marina Pretolani,Marina Pretolani +12 more
TL;DR: It is found that smokers with COPD, but not asthmatics, had higher chitinolytic activity and increased levels of ChTRase in bronchoalveolar lavage, more Ch TRase-positive cells in bronchial biopsies, and an elevated proportion of alveolar macrophages expressing ChTR enzyme than smokers without COPD or never-smokers.