G
Gunnar Pejler
Researcher at Uppsala University
Publications - 227
Citations - 10619
Gunnar Pejler is an academic researcher from Uppsala University. The author has contributed to research in topics: Mast cell & Chymase. The author has an hindex of 54, co-authored 204 publications receiving 9302 citations. Previous affiliations of Gunnar Pejler include Swedish University of Agricultural Sciences.
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Journal ArticleDOI
Mast cell secretory granules: armed for battle
Sara Wernersson,Gunnar Pejler +1 more
TL;DR: The current knowledge of mast cell secretory granules is discussed, which shows that mast cell granule proteases account for many of the protective and detrimental effects of mast cells in various inflammatory settings.
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Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme
Erik Forsberg,Gunnar Pejler,Maria Ringvall,Carolina Lunderius,Bianca R. Tomasini-Johansson,Marion Kusche-Gullberg,Inger Eriksson,Johan Ledin,Lars Hellman,Lena Kjellén +9 more
TL;DR: The results indicate that one site of physiological action for heparin could be inside connective-tissue-type mast cells, where its absence results in severe defects in the secretory granules.
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Mice lacking histidine decarboxylase exhibit abnormal mast cells
Hiroshi Ohtsu,Satoshi Tanaka,Tadashi Terui,Yoshio Hori,Yoko Makabe-Kobayashi,Gunnar Pejler,Elena Tchougounova,Lars Hellman,Marina Gertsenstein,Noriyasu Hirasawa,Eiko Sakurai,Edit I. Buzás,Péter Kovács,György Csaba,Ágnes Kittel,Mikiko Okada,Masahiro Hara,Lynn Mar,Keiko Numayama-Tsuruta,Satsuki Ishigaki-Suzuki,Kazuo Ohuchi,Atsushi Ichikawa,András Falus,Takehiko Watanabe,Andras Nagy,Andras Nagy +25 more
TL;DR: These HDC‐deficient mice are viable and fertile but exhibit a decrease in the numbers of mast cells while the remaining mast cells show an altered morphology and reduced granular content.
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Mast Cells Can Enhance Resistance to Snake and Honeybee Venoms
Martin Metz,Adrian M. Piliponsky,Ching-Cheng Chen,Verena Lammel,Magnus Åbrink,Gunnar Pejler,Mindy Tsai,Stephen J. Galli +7 more
TL;DR: It is shown that mast cells can significantly reduce snake-venom–induced pathology in mice, at least in part by releasing carboxypeptidase A and possibly other proteases, which can degrade venom components.
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Mast cell proteases: multifaceted regulators of inflammatory disease
TL;DR: MC proteases may account for many of the effects ascribed to MCs and are currently emerging as promising candidates for treatment of MC-driven disease, according to a review of the findings.