Mario Pedrazzoli

TL;DR: In situ hybridization of the perifornical area and peptide radioimmunoassays indicated global loss of hypocretins, without gliosis or signs of inflammation in all human cases examined, indicating most cases of human narcolepsy are associated with a deficient hypocretin system.

TL;DR: The data support the hypothesis that access to electricity delays sleep timing, and the higher sleep quality in the urban population also suggests that some aspects of industrialisation are beneficial to sleep.

TL;DR: The results suggest that latitude has a role in the influence of hPer3 gene polymorphism on delayed sleep-phase syndrome and confirm previous data showing its association with morningness-eveningness tendencies.

TL;DR: The results show that there is no association between either polymorphism T3111C or T257G in the Clock gene with diurnal preference or delayed sleep phase syndrome (DSPS), and it is unlikely that this full allele correspondence affects Clock gene expression.

TL;DR: Examining the circadian differences in response to forced activity and homeostatic challenges on hypocretin-1 levels in the cerebrospinal fluid of rats concluded that despite the relation between hypocretins, stress and sleep regulation reported in the literature, short-term total sleep deprivation, immobilization and cold exposure did not induce increases in CSF Hcrt-1 Levels.