J
Juliette Faraco
Researcher at Stanford University
Publications - 51
Citations - 8555
Juliette Faraco is an academic researcher from Stanford University. The author has contributed to research in topics: Narcolepsy & Orexin. The author has an hindex of 27, co-authored 50 publications receiving 8006 citations. Previous affiliations of Juliette Faraco include Howard Hughes Medical Institute.
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Journal ArticleDOI
The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene
Ling Lin,Juliette Faraco,Robin Li,Hiroshi Kadotani,William J. Rogers,X. Lin,Xiaohong Qiu,Pieter J. de Jong,Seiji Nishino,Emmanuel Mignot +9 more
TL;DR: It is determined that canine narcolepsy is caused by disruption of the hypocretin (orexin) receptor 2 gene (Hcrtr2) and this result identifies hypocretins as major sleep-modulating neurotransmitters and opens novel potential therapeutic approaches for Narcoleptic patients.
Journal ArticleDOI
A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
Christelle Peyron,Juliette Faraco,William J. Rogers,Beth Ripley,Sebastiaan Overeem,Sebastiaan Overeem,Yves Charnay,Sona Nevsimalova,Michael S. Aldrich,David Reynolds,Roger L. Albin,Robin Li,Marcel Hungs,Mario Pedrazzoli,Muralidhara Padigaru,Melanie H. Kucherlapati,Jun Fan,Richard A. Maki,Gert Jan Lammers,Constantin Bouras,Raju Kucherlapati,Seiji Nishino,Emmanuel Mignot +22 more
TL;DR: In situ hybridization of the perifornical area and peptide radioimmunoassays indicated global loss of hypocretins, without gliosis or signs of inflammation in all human cases examined, indicating most cases of human narcolepsy are associated with a deficient hypocretin system.
Journal ArticleDOI
Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China.
Fang Han,Ling Lin,Simon C. Warby,Juliette Faraco,Jing Li,Song X. Dong,Pei An,Long Zhao,Ling H. Wang,Qian Y. Li,Han Yan,Zhan C. Gao,Yuan Yuan,Kingman P. Strohl,Emmanuel Mignot +14 more
TL;DR: Narcolepsy is caused by the loss of hypocretin/orexin neurons in the hypothalamus, which is likely the result of an autoimmune process.
Journal ArticleDOI
Narcolepsy is strongly associated with the T-cell receptor alpha locus.
Joachim Hallmayer,Juliette Faraco,Ling Lin,Stephanie Hesselson,Juliane Winkelmann,Minae Kawashima,Minae Kawashima,Geert Mayer,Giuseppe Plazzi,Sona Nevsimalova,Patrice Bourgin,Sheng Seung-Chul Hong,Yutaka Honda,Makoto Honda,Birgit Högl,William T. Longstreth,Jacques Montplaisir,David Kemlink,Mali Einen,Justin Chen,Stacy L. Musone,Matthew Akana,Taku Miyagawa,Jubao Duan,Alex Desautels,Christine Erhardt,Per Egil Hesla,Francesca Poli,Birgit Frauscher,Jong-Hyun Jeong,Sung-Pil Lee,Thanh G.N. Ton,Mark N. Kvale,Libor Kolesar,Marie Dobrovolna,Gerald T. Nepom,Daniel R. Salomon,H-Erich Wichmann,Guy A. Rouleau,Christian Gieger,Douglas F. Levinson,Pablo V. Gejman,Pablo V. Gejman,Thomas Meitinger,Terry Young,Paul E. Peppard,Katsushi Tokunaga,Pui-Yan Kwok,Neil Risch,Neil Risch,Emmanuel Mignot,Emmanuel Mignot +51 more
TL;DR: The authors found association between narcolepsy and polymorphisms in the TRA@ (T-cell receptor alpha) locus, with highest significance at rs1154155 (average allelic odds ratio 1.69, genotypic odds ratios 1.94 and 2.55, P < 10(-21), 1,830 cases, 2,164 controls).
Journal ArticleDOI
Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants.
Tohei Yokogawa,Wilfredo Marin,Juliette Faraco,Guillaume Pézeron,Guillaume Pézeron,Lior Appelbaum,Jian-Jian Zhang,Frédéric M. Rosa,Frédéric M. Rosa,Philippe Mourrain,Emmanuel Mignot,Emmanuel Mignot +11 more
TL;DR: This study validates the use of zebrafish for the study of sleep and indicates molecular diversity in sleep regulatory networks across vertebrates.