S
Sebastiaan Overeem
Researcher at Eindhoven University of Technology
Publications - 293
Citations - 16795
Sebastiaan Overeem is an academic researcher from Eindhoven University of Technology. The author has contributed to research in topics: Narcolepsy & Polysomnography. The author has an hindex of 61, co-authored 262 publications receiving 14868 citations. Previous affiliations of Sebastiaan Overeem include Leiden University Medical Center & Stanford University.
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Journal ArticleDOI
A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
Christelle Peyron,Juliette Faraco,William J. Rogers,Beth Ripley,Sebastiaan Overeem,Sebastiaan Overeem,Yves Charnay,Sona Nevsimalova,Michael S. Aldrich,David Reynolds,Roger L. Albin,Robin Li,Marcel Hungs,Mario Pedrazzoli,Muralidhara Padigaru,Melanie H. Kucherlapati,Jun Fan,Richard A. Maki,Gert Jan Lammers,Constantin Bouras,Raju Kucherlapati,Seiji Nishino,Emmanuel Mignot +22 more
TL;DR: In situ hybridization of the perifornical area and peptide radioimmunoassays indicated global loss of hypocretins, without gliosis or signs of inflammation in all human cases examined, indicating most cases of human narcolepsy are associated with a deficient hypocretin system.
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Hypocretin (orexin) deficiency in human narcolepsy
TL;DR: Alterations in the hypocretin receptor 2 and preprohypocretin genes produce narcolepsy in animal models andHypocretein was undetectable in seven out of nine people with narcoLEpsy, indicating abnormal hypocretIn transmission.
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The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias.
Emmanuel Mignot,Gert Jan Lammers,Beth Ripley,Michele L. Okun,Sonia Nevsimalova,Sebastiaan Overeem,Jitka Vankova,Jed Black,John R. Harsh,Claudio L. Bassetti,Harald Schrader,Seiji Nishino +11 more
TL;DR: Measuring CSF hypocretin-1 is a definitive diagnostic test, provided that it is interpreted within the clinical context, in cases with cataplexy and when the MSLT is difficult to interpret (ie, in subjects already treated with psychoactive drugs or with other concurrent sleep disorders).
Journal ArticleDOI
Hypocretin (orexin) loss in Parkinson's disease
Rolf Fronczek,Sebastiaan Overeem,Sandy Y Y Lee,Ingrid M Hegeman,Johannes van Pelt,Sjoerd G. van Duinen,Gert Jan Lammers,Dick F. Swaab +7 more
TL;DR: The hypocretin-1 concentration in the prefrontal cortex was almost 40% lower in PD patients, while ventricular CSF levels were almost 25% reduced, and the total number of hypoc retin neurons was almost half compared to controls.
Journal ArticleDOI
Low cerebrospinal fluid hypocretin (orexin) and altered energy homeostasis in human narcolepsy
Seiji Nishino,Beth Ripley,Sebastiaan Overeem,Sebastiaan Overeem,Sona Nevsimalova,Gert Jan Lammers,Jitka Vankova,Michele L. Okun,William J. Rogers,Stephen N. Brooks,Emmanuel Mignot +10 more
TL;DR: It is concluded that the hypocretin ligand is deficient in most cases of human narcolepsy, providing possible diagnostic applications and increased BMI and leptin indicate altered energy homeostasis.