M
Marios Dimitriou
Researcher at Karolinska Institutet
Publications - 30
Citations - 759
Marios Dimitriou is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 11, co-authored 18 publications receiving 484 citations. Previous affiliations of Marios Dimitriou include Democritus University of Thrace & Karolinska University Hospital.
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Journal ArticleDOI
Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells
Nicola Guzzi,Maciej Cieśla,Phuong Cao Thi Ngoc,Stefan Lang,Sonali Arora,Marios Dimitriou,Kristyna Pimková,Mikael Sommarin,Roberto Munita,Michal Lubas,Yiting Lim,Kazuki Okuyama,Shamit Soneji,Göran Karlsson,Jenny Hansson,Göran Jönsson,Anders H. Lund,Mikael Sigvardsson,Mikael Sigvardsson,Eva Hellström-Lindberg,Andrew C. Hsieh,Cristian Bellodi +21 more
TL;DR: It is shown that a Ψ-driven posttranscriptional program steers translation control to impact stem cell commitment during early embryogenesis, and a critical function of Ψ is unveiled in directing translation control in stem cells with important implications for development and disease.
Journal ArticleDOI
Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis
Anthie Yiakouvaki,Marios Dimitriou,Ioannis Karakasiliotis,Christina Eftychi,Stamatis Theocharis,Dimitris L. Kontoyiannis +5 more
TL;DR: It is shown that HuR maintains inflammatory homeostasis by controlling macrophage plasticity and migration and demonstrates the potential of harnessing the effects of HuR for clinical benefit against pathologic inflammation and cancer.
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SF3B1-initiating mutations in MDS-RSs target lymphomyeloid hematopoietic stem cells.
Teresa Mortera-Blanco,Marios Dimitriou,Petter S. Woll,Petter S. Woll,Mohsen Karimi,Edda María Elvarsdóttir,Simona Conte,Magnus Tobiasson,Monika Jansson,Iyadh Douagi,Matahi Moarii,Leonie Saft,Elli Papaemmanuil,Sten Eirik W. Jacobsen,Sten Eirik W. Jacobsen,Eva Hellström-Lindberg +15 more
TL;DR: Evidence is provided of a multipotent lymphomyeloid HSC origin of SF3B1 mutations in MDS-RS patients and a novel in vivo platform for mechanistically and therapeutically exploring SF3 B1 mutated M DS-RS.
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Progression in patients with low- and intermediate-1-risk del(5q) myelodysplastic syndromes is predicted by a limited subset of mutations.
Christian Scharenberg,Valentina Giai,Andrea Pellagatti,Leonie Saft,Marios Dimitriou,Monika Jansson,Martin Jädersten,Alf Grandien,Iyadh Douagi,Donna Neuberg,Katarina LeBlanc,Jacqueline Boultwood,Mohsen Karimi,Sten Eirik W. Jacobsen,Sten Eirik W. Jacobsen,Petter S. Woll,Eva Hellström-Lindberg +16 more
TL;DR: Based on the data, a prospective study is advocated aimed at investigating, in a larger number of cases of del(5q) myelodysplastic syndromes, whether the detection of such mutations before and after lenalidomide treatment can guide clinical decision-making.
Journal ArticleDOI
Aberrant splicing of genes involved in haemoglobin synthesis and impaired terminal erythroid maturation in SF3B1 mutated refractory anaemia with ring sideroblasts
Simona Conte,Shintaro Katayama,Liselotte Vesterlund,Mohsen Karimi,Marios Dimitriou,Monika Jansson,Teresa Mortera-Blanco,Per Unneberg,Elli Papaemmanuil,Birgitta Sander,Tiina Skoog,Peter J. Campbell,Julian Walfridsson,Juha Kere,Eva Hellström-Lindberg +14 more
TL;DR: SF3B1 mutated RARS progenitors display impaired splicing with potential downstream consequences for genes of key importance for haemoglobin synthesis and terminal erythroid differentiation, indicated by mis‐splicing of genes involved in transcription regulation.