P
Petter S. Woll
Researcher at Karolinska Institutet
Publications - 64
Citations - 4699
Petter S. Woll is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Haematopoiesis & Stem cell. The author has an hindex of 29, co-authored 52 publications receiving 3999 citations. Previous affiliations of Petter S. Woll include Karolinska University Hospital & John Radcliffe Hospital.
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Journal ArticleDOI
Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia
Nicolas Goardon,Emanuele Marchi,Ann Atzberger,Lynn Quek,Anna Schuh,Shamit Soneji,Petter S. Woll,Adam J. Mead,Kate A. Alford,R Rout,Salma Chaudhury,Amanda F. Gilkes,Steven Knapper,Kheira Beldjord,Suriya Begum,Susan Rose,Nicola Geddes,Mike Griffiths,Graham R. Standen,Alexander Sternberg,Jamie Cavenagh,Hannah Hunter,David G. Bowen,Sally Killick,L. G. Robinson,Andrew Price,Elizabeth Macintyre,Paul Virgo,Alan Kenneth Burnett,Charles Craddock,Tariq Enver,Sten Eirik W. Jacobsen,Catherine Porcher,Paresh Vyas +33 more
TL;DR: It is shown that in ∼80% of primary human CD34+ acute myeloid leukemia (AML), two expanded populations with hemopoietic progenitor immunophenotype coexist in most patients, suggesting that in most cases primaryCD34+ AML is a progenitors disease where LSCs acquire abnormal self-renewal potential.
Journal ArticleDOI
Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy
Alejandra Sanjuan-Pla,Iain C. Macaulay,Christina T. Jensen,Petter S. Woll,Tiago C. Luis,Adam J. Mead,Susan Hardman Moore,Susan Hardman Moore,Cintia Carella,Sahoko Matsuoka,Tiphaine Bouriez Jones,Onima Chowdhury,Laura Stenson,Michael Lutteropp,Joanna C.A. Green,Raffaella Facchini,Hanane Boukarabila,Amit Grover,Adriana Gambardella,Supat Thongjuea,Joana Carrelha,Paul Tarrant,Deborah Atkinson,Sally Ann Clark,Claus Nerlov,Claus Nerlov,Claus Nerlov,Sten Eirik W. Jacobsen +27 more
TL;DR: Findings show that HSC subtypes can be organized into a cellular hierarchy, with platelet-primed HSCs at the apex, and demonstrate that molecular and functional priming for platelet development initiates already in a distinct HSC population.
Journal ArticleDOI
Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia
Alice Giustacchini,Supat Thongjuea,Nikolaos Barkas,Petter S. Woll,Benjamin J. Povinelli,Christopher A.G. Booth,Paul Sopp,Ruggiero Norfo,Alba Rodriguez-Meira,Neil Ashley,Lauren Jamieson,Paresh Vyas,Kristina Anderson,Åsa Segerstolpe,Hong Qian,Ulla Olsson-Strömberg,Satu Mustjoki,Rickard Sandberg,Rickard Sandberg,Sten Eirik W. Jacobsen,Adam J. Mead,Adam J. Mead +21 more
TL;DR: A method that combines high-sensitivity mutation detection with whole-transcriptome analysis of the same single cell is developed, illustrating how single-cell analysis can identify subpopulations of therapy-resistant SCs that are not apparent through cell-population analysis.
Journal ArticleDOI
Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo
Petter S. Woll,Una Kjällquist,Onima Chowdhury,Helen Doolittle,David C. Wedge,Supat Thongjuea,Rikard Erlandsson,Mtakai Ngara,Kristina Anderson,Qiaolin Deng,Adam J. Mead,Laura Stenson,Alice Giustacchini,Sara Duarte,Eleni Giannoulatou,Stephen Taylor,Mohsen Karimi,Christian Scharenberg,Teresa Mortera-Blanco,Iain C. Macaulay,Sally Ann Clark,Ingunn Dybedal,Dag Josefsen,Pierre Fenaux,Peter Hokland,Mette Holm,Mario Cazzola,Luca Malcovati,Sudhir Tauro,David G. Bowen,Jacqueline Boultwood,Andrea Pellagatti,John E. Pimanda,Ashwin Unnikrishnan,Paresh Vyas,Gudrun Göhring,Brigitte Schlegelberger,Magnus Tobiasson,Gunnar Kvalheim,Stefan N. Constantinescu,Claus Nerlov,Lennart Nilsson,Peter J. Campbell,Rickard Sandberg,Elli Papaemmanuil,Eva Hellström-Lindberg,Sten Linnarsson,Sten Eirik W. Jacobsen,Sten Eirik W. Jacobsen +48 more
TL;DR: The existence of rare multipotent MDS stem cells (MDS-SCs), and their hierarchical relationship to lineage-restricted MDS progenitors, are established, with extensive implications for the targeting of the cells required and sufficient for MDS-propagation.
Journal ArticleDOI
Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells.
Joana Carrelha,Yiran Meng,Laura M. Kettyle,Tiago C. Luis,Ruggiero Norfo,Verónica Alcolea,Hanane Boukarabila,Hanane Boukarabila,Francesca Grasso,Francesca Grasso,Adriana Gambardella,Amit Grover,Kari Högstrand,Allegra M. Lord,Alejandra Sanjuan-Pla,Petter S. Woll,Petter S. Woll,Claus Nerlov,Sten Eirik W. Jacobsen +18 more
TL;DR: A limited repertoire of distinct HSC subsets is uncovered, defined by a predictable and hierarchical propensity to adopt a fate towards replenishment of a restricted set of blood lineages, before loss of self-renewal and multipotency.