Marisa Helena Gennari de Medeiros

TL;DR: Emphasis is placed in this Review on the description of the main oxidation reactions initiated by 1O2 and the resulting modifications within key cellular targets, including guanine for nucleic acids, unsaturated lipids, and targeted amino acids.

TL;DR: The results demonstrate that mild mitochondrial uncoupling is a highly effective in vivo antioxidant strategy, and describe the first therapeutic intervention capable of effectively reproducing the physiological, metabolic and lifespan effects of caloric restriction in healthy mammals.

TL;DR: This result clearly demonstrates that singlet oxygen, when released within cells, is able to directly oxidize cellular DNA.

TL;DR: This review summarizes the data obtained in some studies carried out in bivalves from the Brazilian coast subjected to different stress conditions, including the exposure to different contaminants in the laboratory and in the field.

TL;DR: This work addresses the importance of isotope labeling associated with mass spectrometry technique for biomolecule damage studies and provides the first evidence of the occurrence of 1,N(2)-epsilondGuo as a basal endogenous lesion and may be utilized to better assess the biological consequences of etheno DNA damage under normal and pathological conditions.