M
Marjolijn Duijvestein
Researcher at Leiden University Medical Center
Publications - 64
Citations - 2288
Marjolijn Duijvestein is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 15, co-authored 29 publications receiving 1879 citations. Previous affiliations of Marjolijn Duijvestein include Korle Bu Teaching Hospital & Erasmus University Rotterdam.
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Journal ArticleDOI
Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study
Marjolijn Duijvestein,Anne Christine W. Vos,Helene Roelofs,Manon E. Wildenberg,Barbara B. Wendrich,H. W. Verspaget,Engelina Maria Christina Kooy-Winkelaar,Frits Koning,Jaap Jan Zwaginga,Herma H. Fidder,Auke P. Verhaar,Willem E. Fibbe,Gijs R. van den Brink,Daniel W. Hommes +13 more
TL;DR: Administration of autologous bone marrow derived MSCs appears safe and feasible in the treatment of refractory Crohn's disease.
Journal ArticleDOI
Pretreatment with interferon-γ enhances the therapeutic activity of mesenchymal stromal cells in animal models of colitis.
Marjolijn Duijvestein,Manon E. Wildenberg,Mick M. Welling,Simone D. Hennink,Ilse Molendijk,Vanessa L. van Zuylen,Tjalling Bosse,Anne Christine W. Vos,Eveline S.M. de Jonge-Muller,Helene Roelofs,Louise van der Weerd,Hein W. Verspaget,Willem E. Fibbe,Anje A. te Velde,Gijs R. van den Brink,Daniel W. Hommes +15 more
TL;DR: It is demonstrated that IFN‐γ activation of MSCs increases their immunosuppresive capacities and importantly, their therapeutic efficacy in vivo, and prestimulation of MMSs with IFN-γ enhances their capacity to inhibit Th1 inflammatory responses, resulting in diminished mucosal damage in experimental colitis.
Journal ArticleDOI
Allogeneic Bone Marrow–Derived Mesenchymal Stromal Cells Promote Healing of Refractory Perianal Fistulas in Patients With Crohn’s Disease
Ilse Molendijk,Bert A. Bonsing,Helene Roelofs,Koen C.M.J. Peeters,Martin N. J. M. Wasser,Gerard Dijkstra,C. Janneke van der Woude,Marjolijn Duijvestein,Roeland A. Veenendaal,Jaap-Jan Zwaginga,Hein W. Verspaget,Willem E. Fibbe,Andrea E. van der Meulen-de Jong,Daniel W. Hommes,Daniel W. Hommes +14 more
TL;DR: Local administration of allogeneic MSCs was not associated with severe adverse events in patients with perianal fistulizing Crohn's disease and injection of 3 × 10(7) M SCs appeared to promote healing of perianals fistulas.
Journal ArticleDOI
Anti-tumor necrosis factor-α antibodies induce regulatory macrophages in an Fc region-dependent manner.
Anne Christine W. Vos,Manon E. Wildenberg,Marjolijn Duijvestein,Auke P. Verhaar,Gijs R. van den Brink,Daniel W. Hommes +5 more
TL;DR: Regulatory macrophages had an immunosuppressive phenotype because they inhibit proliferation of activated T cells, produce anti-inflammatory cytokines, and express the regulatory macrophage marker CD206.
Journal ArticleDOI
Regulatory macrophages induced by infliximab are involved in healing in vivo and in vitro
Anne Christine W. Vos,Manon E. Wildenberg,Manon E. Wildenberg,Ingrid Arijs,Marjolijn Duijvestein,Auke P. Verhaar,Gert De Hertogh,Severine Vermeire,Paul Rutgeerts,Gijs R. van den Brink,Gijs R. van den Brink,Daniel W. Hommes +11 more
TL;DR: Data show that regulatory macrophages may be involved in mucosal healing and provide a rationale for the superiority of infliximab/azathioprine combination treatment observed in the clinic.