H
Helene Roelofs
Researcher at Leiden University Medical Center
Publications - 71
Citations - 8347
Helene Roelofs is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Mesenchymal stem cell & Transplantation. The author has an hindex of 35, co-authored 70 publications receiving 7538 citations. Previous affiliations of Helene Roelofs include Leiden University.
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Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study.
Katarina Le Blanc,Francesco Frassoni,Lynne M. Ball,Franco Locatelli,Helene Roelofs,Ian D. Lewis,Edoardo Lanino,Berit Sundberg,Maria Ester Bernardo,Mats Remberger,Giorgio Dini,R. Maarten Egeler,Andrea Bacigalupo,Willem E. Fibbe,Olle Ringdén +14 more
TL;DR: Infusion of mesenchymal stem cells expanded in vitro, irrespective of the donor, might be an effective therapy for patients with steroid-resistant, acute GVHD.
Journal ArticleDOI
Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study
Marjolijn Duijvestein,Anne Christine W. Vos,Helene Roelofs,Manon E. Wildenberg,Barbara B. Wendrich,H. W. Verspaget,Engelina Maria Christina Kooy-Winkelaar,Frits Koning,Jaap Jan Zwaginga,Herma H. Fidder,Auke P. Verhaar,Willem E. Fibbe,Gijs R. van den Brink,Daniel W. Hommes +13 more
TL;DR: Administration of autologous bone marrow derived MSCs appears safe and feasible in the treatment of refractory Crohn's disease.
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Cotransplantation of ex vivo expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation.
Lynne M. Ball,Maria Ester Bernardo,Helene Roelofs,Arjan C. Lankester,Angela Cometa,R. Maarten Egeler,Franco Locatelli,Willem E. Fibbe +7 more
TL;DR: The data suggest that MSCs, possibly thanks to their potent immunosuppressive effect on alloreactive host T lymphocytes escaping the preparative regimen, reduce the risk of graft failure in haploidentical HSC transplant recipients.
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Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem cell antigen-1
Venkata Lokesh Battula,Sabrina Treml,Petra M. Bareiss,Friederike Gieseke,Helene Roelofs,Peter de Zwart,Ingo Müller,Bernhard Schewe,Thomas Skutella,Willem E. Fibbe,Lothar Kanz,Hans-Jörg Bühring +11 more
TL;DR: The data suggest that the MSCA-1+CD56+ subset is an attractive starting population for autologous chondrocyte transplantation, and a panel of monoclonal antibodies with superior selectivity for mesenchymal stem cells with distinct phenotypic and functional properties were identified.
Journal ArticleDOI
Multipotent Stromal Cells Induce Human Regulatory T Cells Through a Novel Pathway Involving Skewing of Monocytes Toward Anti-inflammatory Macrophages
Sara M. Melief,Ellen Schrama,Martijn H. Brugman,Machteld M. Tiemessen,Martin J. Hoogduijn,Willem E. Fibbe,Helene Roelofs +6 more
TL;DR: Using an in vitro culture system, it was shown that culture‐expanded bone marrow‐derived MSC promote the generation of CD4+CD25hiFoxP3+ T cells in human PBMC populations and that these populations are functionally suppressive.