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Mark J. Bailey

Researcher at Icahn School of Medicine at Mount Sinai

Publications -  19
Citations -  1567

Mark J. Bailey is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Antibody & Hemagglutinin (influenza). The author has an hindex of 10, co-authored 19 publications receiving 1098 citations. Previous affiliations of Mark J. Bailey include Lawrence Berkeley National Laboratory.

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Journal ArticleDOI

Robust neutralizing antibodies to SARS-CoV-2 infection persist for months.

TL;DR: The vast majority of infected individuals with mild-to-moderate COVID-19 experience robust immunoglobulin G antibody responses against the viral spike protein, and titers are relatively stable for at least a period of about 5 months and that anti-spike binding titers significantly correlate with neutralization of authentic SARS-CoV-2.
Posted ContentDOI

SARS-CoV-2 infection induces robust, neutralizing antibody responses that are stable for at least three months

TL;DR: It is reported that the vast majority of infected individuals with mild-to-moderate COVID-19 experience robust IgG antibody responses against the viral spike protein, and that anti-spike binding titers significantly correlate with neutralization of authentic SARS-CoV-2.
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Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact.

TL;DR: It is demonstrated that the receptor-binding domain of the HA is required to bind to sialic acid expressed on the surface of effector cells to optimize effector cell activation, and this finding provides a basic understanding of how an optimal antibody-dependent cell-mediated response against influenza virus is achieved and may allow for better vaccine design.
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Broadly Neutralizing Hemagglutinin Stalk-Specific Antibodies Induce Potent Phagocytosis of Immune Complexes by Neutrophils in an Fc-Dependent Manner

TL;DR: Evidence is provided that broadly neutralizing HA stalk-specific antibodies induce downstream Fc-mediated neutrophil effector functions that will inform the rational design of improved influenza virus vaccines and therapeutics.