M
Mark J. Bailey
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 19
Citations - 1567
Mark J. Bailey is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Antibody & Hemagglutinin (influenza). The author has an hindex of 10, co-authored 19 publications receiving 1098 citations. Previous affiliations of Mark J. Bailey include Lawrence Berkeley National Laboratory.
Papers
More filters
Journal ArticleDOI
Robust neutralizing antibodies to SARS-CoV-2 infection persist for months.
Ania Wajnberg,Fatima Amanat,Adolfo Firpo,Deena R. Altman,Mark J. Bailey,Mayce Mansour,Meagan McMahon,Philip Meade,Damodara Rao Mendu,Kimberly Muellers,Daniel Stadlbauer,Kimberly Stone,Shirin Strohmeier,Viviana Simon,Judith A. Aberg,David Reich,Florian Krammer,Carlos Cordon-Cardo +17 more
TL;DR: The vast majority of infected individuals with mild-to-moderate COVID-19 experience robust immunoglobulin G antibody responses against the viral spike protein, and titers are relatively stable for at least a period of about 5 months and that anti-spike binding titers significantly correlate with neutralization of authentic SARS-CoV-2.
Posted ContentDOI
SARS-CoV-2 infection induces robust, neutralizing antibody responses that are stable for at least three months
Ania Wajnberg,Fatima Amanat,Adolfo Firpo,Deena R. Altman,Mark J. Bailey,Mayce Mansour,Meagan McMahon,Philip Meade,Damodara Rao Mendu,Kimberly Muellers,Daniel Stadlbauer,Kimberly Stone,Shirin Strohmeier,Judith A. Aberg,David Reich,Florian Krammer,Carlos Cordon-Cardo +16 more
TL;DR: It is reported that the vast majority of infected individuals with mild-to-moderate COVID-19 experience robust IgG antibody responses against the viral spike protein, and that anti-spike binding titers significantly correlate with neutralization of authentic SARS-CoV-2.
Journal ArticleDOI
Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact.
Paul E. Leon,Wenqian He,Caitlin E. Mullarkey,Mark J. Bailey,Matthew S. Miller,Florian Krammer,Peter Palese,Gene S. Tan +7 more
TL;DR: It is demonstrated that the receptor-binding domain of the HA is required to bind to sialic acid expressed on the surface of effector cells to optimize effector cell activation, and this finding provides a basic understanding of how an optimal antibody-dependent cell-mediated response against influenza virus is achieved and may allow for better vaccine design.
Journal ArticleDOI
Broadly Neutralizing Hemagglutinin Stalk-Specific Antibodies Induce Potent Phagocytosis of Immune Complexes by Neutrophils in an Fc-Dependent Manner
Caitlin E. Mullarkey,Mark J. Bailey,Diana Golubeva,Gene S. Tan,Raffael Nachbagauer,Wenqian He,Kyle E. Novakowski,Dawn M. E. Bowdish,Matthew S. Miller,Peter Palese +9 more
TL;DR: Evidence is provided that broadly neutralizing HA stalk-specific antibodies induce downstream Fc-mediated neutrophil effector functions that will inform the rational design of improved influenza virus vaccines and therapeutics.
Journal ArticleDOI
Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model.
Mark J. Bailey,James Duehr,Harrison Dulin,Felix Broecker,Julia A. Brown,Fortuna Arumemi,Maria C. Bermúdez González,Victor H. Leyva-Grado,Matthew J. Evans,Viviana Simon,Jean K. Lim,Florian Krammer,Rong Hai,Peter Palese,Gene S. Tan,Gene S. Tan +15 more
TL;DR: In this article, four monoclonal antibodies (mAbs) from an infected patient that target the non-structural protein NS1 were identified and compared to other mAbs.