C
Caitlin E. Mullarkey
Researcher at McMaster University
Publications - 24
Citations - 1613
Caitlin E. Mullarkey is an academic researcher from McMaster University. The author has contributed to research in topics: Influenza A virus & Hemagglutinin (influenza). The author has an hindex of 17, co-authored 23 publications receiving 1345 citations. Previous affiliations of Caitlin E. Mullarkey include University of Oxford & Mount Sinai Hospital.
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Journal ArticleDOI
Preliminary Assessment of the Efficacy of a T-Cell–Based Influenza Vaccine, MVA-NP+M1, in Humans
Patrick J. Lillie,Tamara Berthoud,Timothy J. Powell,Teresa Lambe,Caitlin E. Mullarkey,Alexandra J. Spencer,Matthew Hamill,Yanchun Peng,Marie Eve Blais,Christopher J A Duncan,Susanne H. Sheehy,Tom Havelock,Saul N. Faust,Rob Lambkin Williams,Anthony Gilbert,John S. Oxford,Tao Dong,Adrian V. S. Hill,Sarah C. Gilbert +18 more
TL;DR: A single vaccination with MVA-NP+M1 boosts T-cell responses to conserved influenza antigens in humans and protects against influenza disease and virus shedding in a challenge study.
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Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection.
Carole J. Henry Dunand,Paul E. Leon,Min Huang,Angela Choi,Veronika Chromikova,Irvin Y. Ho,Gene S. Tan,John Cruz,Ariana Hirsh,Nai-Ying Zheng,Caitlin E. Mullarkey,Francis A. Ennis,Masanori Terajima,John J. Treanor,David J. Topham,Kanta Subbarao,Peter Palese,Florian Krammer,Patrick C. Wilson +18 more
TL;DR: The broadly cross-reactive non-neutralizing antibodies generated in this study were protective through Fc-mediated effector cell recruitment and provide a better understanding of the human monoclonal antibody response to influenza in the context of vaccines.
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Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus
Wenqian He,Gene S. Tan,Caitlin E. Mullarkey,Amanda J. Lee,Mannie Man Wai Lam,Florian Krammer,Carole Henry,Patrick C. Wilson,Ali A. Ashkar,Peter Palese,Matthew S. Miller +10 more
TL;DR: The data demonstrate that antibody specificity plays an important role in the regulation of ADCC, and that cross-talk among antibodies of varying specificities determines the magnitude of Fc receptor-mediated effector functions.
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Original Antigenic Sin: How First Exposure Shapes Lifelong Anti-Influenza Virus Immune Responses.
TL;DR: How the understanding of OAS has progressed from its initial description is reviewed and important outstanding questions in need of further study are highlighted.
Journal ArticleDOI
Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice
Wenqian He,Chi-Jene Chen,Caitlin E. Mullarkey,Jennifer Hamilton,Christine K. Wong,Paul E. Leon,Melissa B. Uccellini,Veronika Chromikova,Carole Henry,Kevin W. Hoffman,Jean K. Lim,Patrick C. Wilson,Matthew S. Miller,Florian Krammer,Peter Palese,Gene S. Tan,Gene S. Tan +16 more
TL;DR: It is demonstrated that alveolar macrophages play a dominant role in conferring protection provided by both broadly neutralizing and non-neutralizing antibodies in mice, and the importance of innate effector cells in establishing a broad-spectrum antiviral state is highlighted.