M
Mark J Dunning
Researcher at University of Sheffield
Publications - 62
Citations - 14165
Mark J Dunning is an academic researcher from University of Sheffield. The author has contributed to research in topics: Cancer & Gene expression profiling. The author has an hindex of 27, co-authored 56 publications receiving 12523 citations. Previous affiliations of Mark J Dunning include University of Cambridge & Norwich University.
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Journal ArticleDOI
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
Christina Curtis,Christina Curtis,Sohrab P. Shah,Suet-Feung Chin,Gulisa Turashvili,Oscar M. Rueda,Mark J Dunning,Doug Speed,Doug Speed,Andy G. Lynch,Shamith A. Samarajiwa,Yinyin Yuan,Stefan Gräf,Gavin Ha,Gholamreza Haffari,Ali Bashashati,Roslin Russell,Steven McKinney,Anita Langerød,Andrew R. Green,Elena Provenzano,Gordon C. Wishart,Sarah E Pinder,Peter H. Watson,Peter H. Watson,Florian Markowetz,Leigh C. Murphy,Ian O. Ellis,Arnie Purushotham,Arnie Purushotham,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,James D. Brenton,Simon Tavaré,Carlos Caldas,Samuel Aparicio +35 more
TL;DR: The results provide a novel molecular stratification of the breast cancer population, derived from the impact of somatic CNAs on the transcriptome, and identify novel subgroups with distinct clinical outcomes, which reproduced in the validation cohort.
Journal ArticleDOI
Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer
Sarah-Jane Dawson,Dana W.Y. Tsui,Muhammed Murtaza,Heather Biggs,Oscar M. Rueda,Suet-Feung Chin,Mark J Dunning,Davina Gale,Tim Forshew,Betania Mahler-Araujo,Sabrina Rajan,Sean Humphray,Jennifer Becq,David Halsall,Matthew G. Wallis,David Bentley,Carlos Caldas,Nitzan Rosenfeld +17 more
TL;DR: This proof-of-concept analysis showed that circulating tumor DNA is an informative, inherently specific, and highly sensitive biomarker of metastatic breast cancer.
Journal ArticleDOI
Relative Impact of Nucleotide and Copy Number Variation on Gene Expression Phenotypes
Barbara E. Stranger,Matthew S. Forrest,Mark J Dunning,Catherine E. Ingle,Claude Beazley,Natalie P. Thorne,Richard Redon,Christine P. Bird,Anna De Grassi,Charles Lee,Charles Lee,Chris Tyler-Smith,Nigel P. Carter,Stephen W. Scherer,Stephen W. Scherer,Simon Tavaré,Simon Tavaré,Panagiotis Deloukas,Matthew E. Hurles,Emmanouil T. Dermitzakis +19 more
TL;DR: To determine the overall contribution of CNVs to complex phenotypes, association analyses of expression levels with SNPs and CNVs in individuals who are part of the International HapMap project show little overlap between the two types of variation.
Journal ArticleDOI
Population genomics of human gene expression
Barbara E. Stranger,Alexandra C. Nica,Matthew S. Forrest,Antigone S. Dimas,Christine P. Bird,Claude Beazley,Catherine E. Ingle,Mark J Dunning,Paul Flicek,Daphne Koller,Stephen B. Montgomery,Simon Tavaré,Panagiotis Deloukas,Emmanouil T. Dermitzakis +13 more
TL;DR: It is found that gene expression is heritable and that differentiation between populations is in agreement with earlier small-scale studies, and the results strongly support an abundance of cis-regulatory variation in the human genome.
Journal ArticleDOI
MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype
Cherie Blenkiron,Leonard D. Goldstein,Natalie P. Thorne,Inmaculada Spiteri,Suet-Feung Chin,Mark J Dunning,Nuno L. Barbosa-Morais,Andrew E. Teschendorff,Andrew R. Green,Ian O. Ellis,Simon Tavaré,Carlos Caldas,Eric A. Miska,Eric A. Miska +13 more
TL;DR: This study represents the first integrated analysis of miRNA expression, mRNA expression and genomic changes in human breast cancer and may serve as a basis for functional studies of the role of miRNAs in the etiology of breast cancer.