B
Betania Mahler-Araujo
Researcher at University of Cambridge
Publications - 9
Citations - 1988
Betania Mahler-Araujo is an academic researcher from University of Cambridge. The author has contributed to research in topics: Induced pluripotent stem cell & Cancer. The author has an hindex of 4, co-authored 7 publications receiving 1705 citations. Previous affiliations of Betania Mahler-Araujo include Cambridge University Hospitals NHS Foundation Trust.
Papers
More filters
Journal ArticleDOI
Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer
Sarah-Jane Dawson,Dana W.Y. Tsui,Muhammed Murtaza,Heather Biggs,Oscar M. Rueda,Suet-Feung Chin,Mark J Dunning,Davina Gale,Tim Forshew,Betania Mahler-Araujo,Sabrina Rajan,Sean Humphray,Jennifer Becq,David Halsall,Matthew G. Wallis,David Bentley,Carlos Caldas,Nitzan Rosenfeld +17 more
TL;DR: This proof-of-concept analysis showed that circulating tumor DNA is an informative, inherently specific, and highly sensitive biomarker of metastatic breast cancer.
Journal ArticleDOI
Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner.
Ralitsa R. Madsen,Rachel G. Knox,Rachel G. Knox,Wayne Pearce,Saioa López,Betania Mahler-Araujo,Nicholas McGranahan,Bart Vanhaesebroeck,Robert K. Semple +8 more
TL;DR: It is suggested that a PI3K activity threshold determines pathological consequences of oncogenic PIK3CA activation and insight is provided into the specific role of this pathway in human pluripotent stem cells.
Journal ArticleDOI
Astronomical algorithms for automated analysis of tissue protein expression in breast cancer
Ali Hr,Mike Irwin,Lorna Morris,Sarah-Jane Dawson,Fiona M. Blows,Elena Provenzano,Betania Mahler-Araujo,Paul D.P. Pharoah,Nicholas A. Walton,James D. Brenton,Carlos Caldas +10 more
TL;DR: The adaptation of astronomical algorithms coupled with their application to large annotated study cohorts, constitutes a powerful tool for the realisation of the enormous potential of digital pathology.
Posted ContentDOI
Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner
Ralitsa R. Madsen,Ralitsa R. Madsen,Ralitsa R. Madsen,Rachel G. Knox,Rachel G. Knox,Wayne Pearce,Saioa López,Betania Mahler-Araujo,Betania Mahler-Araujo,Nicholas McGranahan,Bart Vanhaesebroeck,Robert K. Semple,Robert K. Semple,Robert K. Semple +13 more
TL;DR: It is suggested that a PI3K activity threshold determines pathological consequences of oncogenic PIK3CA activation and the first insight is provided into the specific role of this pathway in human pluripotent stem cells.
Journal ArticleDOI
SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation.
Guillaume Bidault,Samuel Virtue,Kasparas Petkevicius,Helen E. Jolin,Aurelien Dugourd,Aurelien Dugourd,Anne-Claire Guénantin,Anne-Claire Guénantin,Jennifer Leggat,Betania Mahler-Araujo,Brian Y H Lam,Marcella Ma,Martin Dale,Stefania Carobbio,Stefania Carobbio,Arthur Kaser,Padraic G. Fallon,Julio Saez-Rodriguez,Andrew N J McKenzie,Antonio Vidal-Puig,Antonio Vidal-Puig +20 more
TL;DR: In this paper, the anabolic transcription factor sterol regulatory element binding protein 1 (SREBP1) is activated in response to the canonical T helper 2 cell cytokine interleukin-4 to trigger the de novo lipogenesis (DNL) program, as a necessary step for macrophage alternative activation.