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Inmaculada Spiteri
Researcher at Institute of Cancer Research
Publications - 36
Citations - 5838
Inmaculada Spiteri is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 22, co-authored 34 publications receiving 4888 citations. Previous affiliations of Inmaculada Spiteri include Cancer Research UK & Norwich University.
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Journal ArticleDOI
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
Andrea Sottoriva,Andrea Sottoriva,Andrea Sottoriva,Inmaculada Spiteri,Sara Grazia Maria Piccirillo,Anestis Touloumis,V. Peter Collins,John C. Marioni,Christina Curtis,Colin Watts,Simon Tavaré,Simon Tavaré,Simon Tavaré +12 more
TL;DR: The genome-wide architecture of intratumor variability in GB is revealed across multiple spatial scales and patient-specific patterns of cancer evolution, with consequences for treatment design.
Journal ArticleDOI
Patient-derived organoids model treatment response of metastatic gastrointestinal cancers
Georgios Vlachogiannis,Somaieh Hedayat,Alexandra Vatsiou,Yann Jamin,Javier Fernández-Mateos,Khurum Khan,Khurum Khan,Andrea Lampis,Katherine Eason,Ian Said Huntingford,Rosemary Burke,Mihaela Rata,Dow-Mu Koh,Dow-Mu Koh,Nina Tunariu,Nina Tunariu,David J. Collins,Sanna Hulkki-Wilson,Chanthirika Ragulan,Inmaculada Spiteri,Sing Yu Moorcraft,Ian Chau,Sheela Rao,David Watkins,Nicos Fotiadis,Maria Antonietta Bali,Maria Antonietta Bali,Mahnaz Darvish-Damavandi,Hazel Lote,Hazel Lote,Zakaria Eltahir,Elizabeth C Smyth,Ruwaida Begum,Paul A. Clarke,Jens C. Hahne,Mitchell Dowsett,Johann S. de Bono,Paul Workman,Anguraj Sadanandam,Matteo Fassan,Owen J. Sansom,Suzanne A. Eccles,Naureen Starling,Chiara Braconi,Chiara Braconi,Andrea Sottoriva,Simon P. Robinson,David Cunningham,Nicola Valeri,Nicola Valeri +49 more
TL;DR: Responses to anticancer agents ex vivo in organoids and PDO-based orthotopic mouse tumor xenograft models with the responses of the patients in clinical trials are compared to suggest that PDOs can recapitulate patient responses in the clinic and could be implemented in personalized medicine programs.
Journal ArticleDOI
MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype
Cherie Blenkiron,Leonard D. Goldstein,Natalie P. Thorne,Inmaculada Spiteri,Suet-Feung Chin,Mark J Dunning,Nuno L. Barbosa-Morais,Andrew E. Teschendorff,Andrew R. Green,Ian O. Ellis,Simon Tavaré,Carlos Caldas,Eric A. Miska,Eric A. Miska +13 more
TL;DR: This study represents the first integrated analysis of miRNA expression, mRNA expression and genomic changes in human breast cancer and may serve as a basis for functional studies of the role of miRNAs in the etiology of breast cancer.
Journal ArticleDOI
Genetic Unmasking of an Epigenetically Silenced microRNA in Human Cancer Cells
Amaia Lujambio,Santiago Ropero,Esteban Ballestar,Mario F. Fraga,Celia Cerrato,Fernando Setien,Sara Casado,Ana Suárez-Gauthier,Montserrat Sanchez-Cespedes,Anna Gitt,Inmaculada Spiteri,Partha Pratim Das,Carlos Caldas,Eric A. Miska,Manel Esteller +14 more
TL;DR: Interestingly, this work functionally link the epigenetic loss of miRNA-124a with the activation of cyclin D kinase 6, a bona fide oncogenic factor, and the phosphorylation of the retinoblastoma, a tumor suppressor gene.
Journal ArticleDOI
Longitudinal Liquid Biopsy and Mathematical Modeling of Clonal Evolution Forecast Time to Treatment Failure in the PROSPECT-C Phase II Colorectal Cancer Clinical Trial.
Khurum Khan,Khurum Khan,David Cunningham,Benjamin Werner,Georgios Vlachogiannis,Inmaculada Spiteri,Timon Heide,Javier Fernandez Mateos,Alexandra Vatsiou,Andrea Lampis,Mahnaz Darvish Damavandi,Hazel Lote,Ian Said Huntingford,Somaieh Hedayat,Ian Chau,Nina Tunariu,Giulia Mentrasti,Francesco Trevisani,Sheela Rao,Gayathri Anandappa,Gayathri Anandappa,David Watkins,Naureen Starling,Janet Thomas,Clare Peckitt,Nasir Khan,Massimo Rugge,Ruwaida Begum,Blanka Hezelova,Annette Bryant,Thomas Jones,Paula Proszek,Matteo Fassan,Jens C. Hahne,Mike Hubank,Chiara Braconi,Chiara Braconi,Andrea Sottoriva,Nicola Valeri,Nicola Valeri +39 more
TL;DR: This study demonstrates how integrating frequently sampled longitudinal liquid biopsies with a mathematical framework of tumor evolution allows individualized quantitative forecasting of progression, providing novel opportunities for adaptive personalized therapies.