D
Doug Speed
Researcher at Aarhus University
Publications - 69
Citations - 9082
Doug Speed is an academic researcher from Aarhus University. The author has contributed to research in topics: Genome-wide association study & Heritability. The author has an hindex of 22, co-authored 56 publications receiving 7101 citations. Previous affiliations of Doug Speed include University of Cambridge & University of Southern California.
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Journal ArticleDOI
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
Christina Curtis,Christina Curtis,Sohrab P. Shah,Suet-Feung Chin,Gulisa Turashvili,Oscar M. Rueda,Mark J Dunning,Doug Speed,Doug Speed,Andy G. Lynch,Shamith A. Samarajiwa,Yinyin Yuan,Stefan Gräf,Gavin Ha,Gholamreza Haffari,Ali Bashashati,Roslin Russell,Steven McKinney,Anita Langerød,Andrew R. Green,Elena Provenzano,Gordon C. Wishart,Sarah E Pinder,Peter H. Watson,Peter H. Watson,Florian Markowetz,Leigh C. Murphy,Ian O. Ellis,Arnie Purushotham,Arnie Purushotham,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,James D. Brenton,Simon Tavaré,Carlos Caldas,Samuel Aparicio +35 more
TL;DR: The results provide a novel molecular stratification of the breast cancer population, derived from the impact of somatic CNAs on the transcriptome, and identify novel subgroups with distinct clinical outcomes, which reproduced in the validation cohort.
Journal ArticleDOI
Improved Heritability Estimation from Genome-wide SNPs
TL;DR: A modified kinship matrix in which SNPs are weighted according to local LD is proposed, which greatly reduces the bias and increases the precision of h(2) estimates and develops LDAK, software for computing LD-adjusted kinships.
Journal ArticleDOI
Reevaluation of SNP heritability in complex human traits
TL;DR: A model that more accurately describes how heritability varies with minor allele frequency, linkage disequilibrium and genotype certainty is empirically derived by analyzing imputed data for a large number of human traits.
Journal ArticleDOI
Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeast.
Daniel C. Jeffares,Clare Jolly,Mimoza Hoti,Doug Speed,Liam P. Shaw,Charalampos Rallis,Charalampos Rallis,Francois Balloux,Christophe Dessimoz,Jürg Bähler,Fritz J. Sedlazeck +10 more
TL;DR: It is shown that copy number variants (CNVs) show a variety of genetic signals consistent with rapid turnover and make substantial contributions to quantitative traits, most notably intracellular amino acid concentrations, growth under stress and sugar utilization in winemaking, whereas rearrangements are strongly associated with reproductive isolation.
Journal ArticleDOI
Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies
Bassel Abou-Khalil,Pauls Auce,Andreja Avbersek,Melanie Bahlo,David J. Balding,Thomas Bast,Larry Baum,Albert J. Becker,Felicitas Becker,Bianca Berghuis,Samuel F. Berkovic,Katja E. Boysen,Jonathan P. Bradfield,Lawrence C. Brody,Russell J. Buono,Ellen Campbell,Gregory D. Cascino,Claudia B. Catarino,Gianpiero L. Cavalleri,Stacey S. Cherny,Krishna Chinthapalli,Alison J. Coffey,Alastair Compston,Antonietta Coppola,Patrick Cossette,John Craig,Gerrit-Jan de Haan,Peter De Jonghe,Carolien G.F. de Kovel,Norman Delanty,Chantal Depondt,Orrin Devinsky,Dennis J. Dlugos,Colin P. Doherty,Christian E. Elger,Johan G. Eriksson,Thomas N. Ferraro,Martha Feucht,Ben Francis,Andre Franke,Jacqueline A. French,Saskia Freytag,Verena Gaus,Eric B. Geller,Christian Gieger,Tracy A. Glauser,Simon Glynn,David Goldstein,Hongsheng Gui,Youling Guo,Kevin Haas,Hakon Hakonarson,Kerstin Hallmann,Sheryl R. Haut,Erin L. Heinzen,Ingo Helbig,Christian Hengsbach,Helle Hjalgrim,Michele Iacomino,Andres Ingason,Jennifer Jamnadas-Khoda,Marvin Johnson,Reetta Kälviäinen,Anne-Mari Kantanen,Dalia Kasperaviciute,Dorothée G.A. Kasteleijn-Nolst Trenité,Heidi E. Kirsch,Robert C. Knowlton,Bobby P. C. Koeleman,Roland Krause,Martin Krenn,Wolfram S. Kunz,Ruben Kuzniecky,Patrick Kwan,Dennis Lal,Yu-Lung Lau,Anna-Elina Lehesjoki,Holger Lerche,Costin Leu,Wolfgang Lieb,Dick Lindhout,Warren D. Lo,Iscia Lopes-Cendes,Daniel H. Lowenstein,Alberto Malovini,Anthony G Marson,Thomas U. Mayer,Mark McCormack,James L. Mills,Nasir Mirza,Martina Moerzinger,Rikke S. Møller,Anne M. Molloy,Hiltrud Muhle,Mark R Newton,Ping-Wing Ng,Markus M. Noethen,Peter Nuernberg,Terence J. O'Brien,Karen Oliver,Aarno Palotie,Faith Pangilinan,Sarah Peter,Slavé Petrovski,Annapurna Poduri,Michael Privitera,Rodney A. Radtke,Sarah Rau,Philipp S. Reif,Eva M. Reinthaler,Felix Rosenow,Josemir W. Sander,Thomas Sander,Theresa Scattergood,Steven C. Schachter,Christoph J. Schankin,Ingrid E. Scheffer,Bettina Schmitz,Susanne Schoch,Pak C. Sham,Jerry J. Shih,Graeme J. Sills,Sanjay M. Sisodiya,Lisa Slattery,Alexander R. H. Smith,David F. Smith,Mike Smith,Philip E. M. Smith,Anja C M Sonsma,Doug Speed,Michael R. Sperling,Bernhard J. Steinhoff,Ulrich Stephani,Remi Stevelink,Konstantin Strauch,Pasquale Striano,H. Stroink,Rainer Surges,K. Meng Tan,Liu Lin Thio,G. Neil Thomas,Marian Todaro,Rossana Tozzi,Maria Stella Vari,Eileen P.G. Vining,Frank Visscher,Sarah von Spiczak,Nicole M. Walley,Yvonne G. Weber,Zhi Wei,Judith L.Z. Weisenberg,Christopher D. Whelan,Peter Widdess-Walsh,Markus Wolff,Stefan Wolking,Wanling Yang,Federico Zara,Fritz Zimprich,Int League Against Epilepsy Conso +158 more
TL;DR: The authors perform genome-wide association studies for 3 broad and 7 subtypes of epilepsy and identify 16 loci - 11 novel - that are further annotated by eQTL and partitioned heritability analyses that provide leads for epilepsy therapies based on underlying pathophysiology.