M
Mark James Milgrew
Researcher at Life Technologies
Publications - 20
Citations - 2569
Mark James Milgrew is an academic researcher from Life Technologies. The author has contributed to research in topics: Signal & Signal-to-noise ratio. The author has an hindex of 7, co-authored 20 publications receiving 2409 citations.
Papers
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Journal ArticleDOI
An integrated semiconductor device enabling non-optical genome sequencing
Jonathan M. Rothberg,Wolfgang Hinz,Todd Rearick,Jonathan Schultz,William J. Mileski,Melville Davey,John H. Leamon,Kim L. Johnson,Mark James Milgrew,Matthew D. Edwards,Jeremy Hoon,Jan Fredrik Simons,David Marran,Jason W. Myers,John F. Davidson,Annika Branting,John Nobile,Bernard P. Puc,David Light,Travis A. Clark,Martin Huber,Jeffrey T. Branciforte,Isaac B. Stoner,Simon Cawley,Michael R. Lyons,Yutao Fu,Nils Homer,Marina Sedova,Xin Miao,Brian Reed,Jeffrey Sabina,Erika Feierstein,Michelle Schorn,Mohammad Alanjary,Eileen T. Dimalanta,Devin Dressman,Rachel Kasinskas,Tanya Sokolsky,Jacqueline A. Fidanza,Eugeni Namsaraev,Kevin McKernan,Alan Williams,G. Thomas Roth,James Bustillo +43 more
TL;DR: A DNA sequencing technology in which scalable, low-cost semiconductor manufacturing techniques are used to make an integrated circuit able to directly perform non-optical DNA sequencing of genomes, showing its robustness and scalability by producing ion chips with up to 10 times as many sensors and sequencing a human genome.
Patent
Integrated sensor arrays for biological and chemical analysis
Jonathan M. Rothberg,James Bustillo,Mark James Milgrew,Jonathan Schultz,David Marran,Todd Rearick,Kim L. Johnson +6 more
TL;DR: In this article, an ion-sensitive field effect transistor has been proposed for large scale pH-based DNA sequencing and other bioscience and biomedical applications, where each of the transistors has a floating gate with a dielectric layer contacting the sample fluid and being capable of accumulating charge in proportion to a concentration of the charged species in the fluid.
Patent
Methods and apparatus for testing isfet arrays
TL;DR: In this article, a chemically-sensitive transistor device, such as an ISFET, is used to test the functionality of the transistor without exposing the device to liquids, and the parasitic capacitance of at least either the source or drain is exploited to bias the floating gate.
Patent
Active chemically-sensitive sensors with in-sensor current sources
TL;DR: In this paper, the authors present methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions.
Patent
Chemically-sensitive field effect transistor based pixel array with protection diodes
TL;DR: In this article, the authors present methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions.