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Michael R. Lyons
Researcher at Life Technologies
Publications - 3
Citations - 2873
Michael R. Lyons is an academic researcher from Life Technologies. The author has contributed to research in topics: DNA sequencing & Population bottleneck. The author has an hindex of 3, co-authored 3 publications receiving 2695 citations.
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Journal ArticleDOI
An integrated semiconductor device enabling non-optical genome sequencing
Jonathan M. Rothberg,Wolfgang Hinz,Todd Rearick,Jonathan Schultz,William J. Mileski,Melville Davey,John H. Leamon,Kim L. Johnson,Mark James Milgrew,Matthew D. Edwards,Jeremy Hoon,Jan Fredrik Simons,David Marran,Jason W. Myers,John F. Davidson,Annika Branting,John Nobile,Bernard P. Puc,David Light,Travis A. Clark,Martin Huber,Jeffrey T. Branciforte,Isaac B. Stoner,Simon Cawley,Michael R. Lyons,Yutao Fu,Nils Homer,Marina Sedova,Xin Miao,Brian Reed,Jeffrey Sabina,Erika Feierstein,Michelle Schorn,Mohammad Alanjary,Eileen T. Dimalanta,Devin Dressman,Rachel Kasinskas,Tanya Sokolsky,Jacqueline A. Fidanza,Eugeni Namsaraev,Kevin McKernan,Alan Williams,G. Thomas Roth,James Bustillo +43 more
TL;DR: A DNA sequencing technology in which scalable, low-cost semiconductor manufacturing techniques are used to make an integrated circuit able to directly perform non-optical DNA sequencing of genomes, showing its robustness and scalability by producing ion chips with up to 10 times as many sensors and sequencing a human genome.
Journal ArticleDOI
Sequence and structural variation in a human genome uncovered by short-read, massively parallel ligation sequencing using two-base encoding
Kevin McKernan,Heather E. Peckham,Gina Costa,Stephen F. McLaughlin,Yutao Fu,Eric F. Tsung,Christopher Clouser,Cisyla Duncan,Jeffrey K. Ichikawa,Clarence Lee,Zheng Zhang,Swati Ranade,Eileen T. Dimalanta,Fiona Hyland,Tanya Sokolsky,Lei Zhang,Andrew Sheridan,Haoning Fu,Cynthia L. Hendrickson,Bin Li,Lev Kotler,Jeremy R. Stuart,Joel A. Malek,Jonathan M. Manning,Alena A. Antipova,Damon S. Perez,Michael P. Moore,Kathleen C. Hayashibara,Michael R. Lyons,Robert E. Beaudoin,Brittany E. Coleman,Michael W. Laptewicz,Adam Sannicandro,Michael D. Rhodes,Rajesh Gottimukkala,Shan Yang,Vineet Bafna,Ali Bashir,Andrew MacBride,Can Alkan,Jeffrey M. Kidd,Evan E. Eichler,Martin G. Reese,Francisco M. De La Vega,Alan Blanchard +44 more
TL;DR: Dozens of mutations previously described in OMIM and hundreds of nonsynonymous single-nucleotide and structural variants in genes previously implicated in disease are identified in this individual.
Journal ArticleDOI
Low-Pass Genome-Wide Sequencing and Variant Inference Using Identity-by-Descent in an Isolated Human Population
Alexander Gusev,Minita Shah,Eimear E. Kenny,Arthi Ramachandran,Jennifer K. Lowe,Jennifer K. Lowe,Jennifer K. Lowe,J. Salit,J. Salit,Clarence Lee,Elizabeth Levandowsky,T. N. Weaver,Q. C. Doan,Heather E. Peckham,Stephen F. McLaughlin,Michael R. Lyons,Vrunda Sheth,Markus Stoffel,F. M. De La Vega,Jeffrey M. Friedman,Jan L. Breslow,Itsik Pe'er +21 more
TL;DR: This study presents whole-genome analysis of a homogenous isolate population with emphasis on optimal rare variant inference and identifies long regions with haplotypes co-inherited between pairs of individuals and methodology to leverage such shared genetic content for imputation.