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Rachel Kasinskas
Researcher at Life Technologies
Publications - 15
Citations - 2969
Rachel Kasinskas is an academic researcher from Life Technologies. The author has contributed to research in topics: Nucleic acid & Population. The author has an hindex of 9, co-authored 15 publications receiving 2743 citations. Previous affiliations of Rachel Kasinskas include University of Massachusetts Boston & University of Massachusetts Amherst.
Papers
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Journal ArticleDOI
An integrated semiconductor device enabling non-optical genome sequencing
Jonathan M. Rothberg,Wolfgang Hinz,Todd Rearick,Jonathan Schultz,William J. Mileski,Melville Davey,John H. Leamon,Kim L. Johnson,Mark James Milgrew,Matthew D. Edwards,Jeremy Hoon,Jan Fredrik Simons,David Marran,Jason W. Myers,John F. Davidson,Annika Branting,John Nobile,Bernard P. Puc,David Light,Travis A. Clark,Martin Huber,Jeffrey T. Branciforte,Isaac B. Stoner,Simon Cawley,Michael R. Lyons,Yutao Fu,Nils Homer,Marina Sedova,Xin Miao,Brian Reed,Jeffrey Sabina,Erika Feierstein,Michelle Schorn,Mohammad Alanjary,Eileen T. Dimalanta,Devin Dressman,Rachel Kasinskas,Tanya Sokolsky,Jacqueline A. Fidanza,Eugeni Namsaraev,Kevin McKernan,Alan Williams,G. Thomas Roth,James Bustillo +43 more
TL;DR: A DNA sequencing technology in which scalable, low-cost semiconductor manufacturing techniques are used to make an integrated circuit able to directly perform non-optical DNA sequencing of genomes, showing its robustness and scalability by producing ion chips with up to 10 times as many sensors and sequencing a human genome.
Journal ArticleDOI
Salmonella typhimurium lacking ribose chemoreceptors localize in tumor quiescence and induce apoptosis.
Rachel Kasinskas,Neil S. Forbes +1 more
TL;DR: By deleting the ribose/galactose receptor, bacterial accumulation localized to tumor quiescence and had a greater individual effect on inducing apoptosis than wild-type S. typhimurium.
Journal ArticleDOI
Salmonella typhimurium specifically chemotax and proliferate in heterogeneous tumor tissue in vitro
Rachel Kasinskas,Neil S. Forbes +1 more
TL;DR: Several mechanisms of S. typhimurium accumulation in solid tumors have been quantified, which is an important step in the development of bacterial‐based therapeutics to target tumor quiescence.
Journal ArticleDOI
A multipurpose microfluidic device designed to mimic microenvironment gradients and develop targeted cancer therapeutics
Colin L. Walsh,Brett M. Babin,Rachel Kasinskas,Jean A. Foster,Marissa J. McGarry,Neil S. Forbes +5 more
TL;DR: A microfluidic device that mimics the microenvironment gradients present in tumors that will enable the development of more effective cancer therapies and will be vital for understanding the behavior of common cancer drugs in solid tumors and designing novel intratumorally targeted therapeutics.
Patent
Nucleic acid amplification
Chieh-Yuan Li,David Ruff,Jennifer O'neil,Rachel Kasinskas,Shiaw-Min Chen,Jonathan M. Rothberg +5 more
TL;DR: In this article, the present teachings provide methods for nucleic acid amplification, comprising forming a reaction mixture, and subjecting the reaction mixture to conditions suitable for NCA, including partially denaturing conditions.