Mark P. White

TL;DR: It is demonstrated that miR-145 can direct the smooth muscle fate and that mi R-145 and miR -143 function to regulate the quiescent versus proliferative phenotype of smooth muscle cells.

TL;DR: In this paper, the authors used human induced pluripotent stem cell (iPSC)-derived endothelial cells (ECs) to show that heterozygous nonsense mutations in NOTCH1 that cause aortic valve calcification disrupt the epigenetic architecture, resulting in derepression of latent pro-osteogenic and -inflammatory gene networks.

TL;DR: It is shown here that X- inactivation status in female hiPSC lines depends on derivation conditions, and feeders are a significant factor affecting X-inactivation status.

TL;DR: A differentiation protocol based on embryonic development that consistently yields large numbers of endothelial cells (ECs) derived from multiple hESCs or iPS cells is reported and individual lineages derived from human iPS Cells may have significantly less variance than their pluripotent founders.

TL;DR: This study provides insights into how FLT1 and vascular endothelial growth factor receptor 2 signaling is titrated in a microRNA-mediated manner and establishes miR-10 as a potential new target for the selective modulation of angiogenesis.