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Sarah U. Morton
Researcher at Harvard University
Publications - 76
Citations - 4897
Sarah U. Morton is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 13, co-authored 49 publications receiving 3898 citations. Previous affiliations of Sarah U. Morton include Boston Children's Hospital & Pennsylvania State University.
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Journal ArticleDOI
miR-126 regulates angiogenic signaling and vascular integrity
Jason E. Fish,Massimo M. Santoro,Sarah U. Morton,Sangho Yu,Ru Fang Yeh,Joshua D. Wythe,Kathryn N. Ivey,Benoit G. Bruneau,Didier Y.R. Stainier,Deepak Srivastava +9 more
TL;DR: It is found that miR-126 regulated the response of endothelial cells to VEGF, providing a new target for modulating vascular formation and function and illustrating that a single miRNA can regulate vascular integrity and angiogenesis.
Journal ArticleDOI
miR-145 and miR-143 regulate smooth muscle cell fate and plasticity
Kimberly R. Cordes,Neil T. Sheehy,Mark P. White,Emily C. Berry,Sarah U. Morton,Alecia N. Muth,Ting-Hein Lee,Joseph M. Miano,Kathryn N. Ivey,Deepak Srivastava +9 more
TL;DR: It is demonstrated that miR-145 can direct the smooth muscle fate and that mi R-145 and miR -143 function to regulate the quiescent versus proliferative phenotype of smooth muscle cells.
Journal ArticleDOI
Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands
Sheng Chih Jin,Jason Homsy,Samir Zaidi,Qiongshi Lu,Sarah U. Morton,Steven R. DePalma,Xue Zeng,Hongjian Qi,Weni Chang,Michael C. Sierant,Wei Chien Hung,Shozeb Haider,Junhui Zhang,James R. Knight,Robert D. Bjornson,Christopher Castaldi,Irina R. Tikhonoa,Kaya Bilguvar,Shrikant Mane,Stephen Sanders,Seema Mital,Mark W. Russell,J. William Gaynor,John E. Deanfield,Alessandro Giardini,George A. Porter,Deepak Srivastava,Cecelia W. Lo,Yufeng Shen,W. Scott Watkins,Mark Yandell,H. Joseph Yost,Martin Tristani-Firouzi,Jane W. Newburger,Amy E. Roberts,Richard B. Kim,Hongyu Zhao,Jonathan R. Kaltman,Elizabeth Goldmuntz,Wendy K. Chung,Jonathan G. Seidman,Bruce D. Gelb,Christine E. Seidman,Richard P. Lifton,Richard P. Lifton,Martina Brueckner +45 more
TL;DR: Exome sequencing of a single cohort of 2,871 CHD probands, including 2,645 parent–offspring trios, implicated rare inherited mutations in 1.8%, and DNMs in ∼440 genes were inferred to contribute to CHD.
Journal ArticleDOI
microRNA-138 modulates cardiac patterning during embryonic development
Sarah U. Morton,Paul Scherz,Kimberly R. Cordes,Kathryn N. Ivey,Didier Y.R. Stainier,Deepak Srivastava +5 more
TL;DR: The findings demonstrate that miR-138 helps establish discrete domains of gene expression during cardiac morphogenesis by targeting multiple members of a common pathway, and also establish the use of antagomiRs in fish for temporal knockdown of miRNA function.
Journal ArticleDOI
Fetal Physiology and the Transition to Extrauterine Life
Sarah U. Morton,Dara Brodsky +1 more
TL;DR: The intrauterine physiology that allows the fetus to survive is explained and the physiologic changes that occur during the transition to extrauterine life are reviewed.