Mark R. Wormald

TL;DR: Results support the rationale for treatment with pharmacological agents that augment levels of functional Q0bolton-AAT protein, thus offering a potential therapeutic option for AATD patients with rare mutations of similar theratype.

TL;DR: The results demonstrate that the ability of TIMP-1 to inhibit MMPs is at least in part regulated by outer arm fucosylation of its N-glycans.

TL;DR: An approach to the synthesis of D-mannopyranose derivatives incorporating an anomeric α-amino acid component is described in this article, where an N-acylated bicyclic [2.2] lactone, formed via an oxidative ring closure, provides access to a new class of glycopeptide analogues of Dmannoprinose and determines the anomericity configuration of compounds derived therefrom.

TL;DR: The results suggest that the potential antigenicity of Fc Neu5Gc is low, which could be referenced in the process design and optimization of mAb production in murine myeloma cells and in the quality control of mAbs for industries and regulatory authorities.

TL;DR: Although there are 32 6-azidoheptitols, there are only 16 homonojirimycin (HNJ) stereoisomers; two epimeric azidoalditols derived from d-mannose allow the synthesis in water of eight stereoisomer of HNJ.