Mark R. Wormald

TL;DR: The 7-O-beta-D xyloside 6 was a stronger competitive inhibitor than 4 of C saccharolyticum beta-glucosidase and rat intestinal lactase, with K(i) values of 0.06 and 0.07 microM, respectively, but a weaker inhibitor of bovine liver beta-galactosidases.

TL;DR: X-ray diffraction and analytical ultracentrifugation data reveal a rod-like arrangement of four short consensus repeat (SCR) domains in both the crystal and solution and suggest that the interaction with the convertase, and thus complement regulation, depends on the burial of a hydrophobic patch centered on the linker between SCR domains 2 and 3.

TL;DR: The purification of a 75-kDa glycoprotein with vitamin E-binding properties by stepwise chromatography of lipoprotein-depleted human plasma and monitoring of vitamin E (alpha-tocopherol)-binding activity complements the in vitro findings for purified native and recombinant afamin and suggests potential roles for afamin in fertility and neuroprotection.

TL;DR: It is shown here that a designed set of nonself, synthetic monosaccharides are potent antigens, and when introduced to the terminus of the D1 arm of protein glycans recognized by 2G12, their antigenicity is significantly enhanced.

TL;DR: 1H-NMR spectroscopy has been used to study the conformation and dynamics of the isolated tailpiece from human serum immunoglobulin M, a 22-residue peptide containing a single asparagine glycosylation site, and various roles for the different glycoforms of the tail peptide are discussed.