Mark S. Lechner

TL;DR: Gene expression profiling demonstrated that Nipbl deficiency leads to modest but significant transcriptional dysregulation of many genes, and expression changes at the protocadherin beta (Pcdhb) locus, as well as at other loci, support the view that NIPBL influences long-range chromosomal regulatory interactions.

TL;DR: It is indicated that proper HP1 status is required for sister-chromatid cohesion in mammalian cells, and suggested that HP1alpha might be required for chromosome condensation, and a "wavy" chromosome morphology is observed.

TL;DR: The method integrates ontology-based semantic tagging, information extraction and data mining together, automatically learns the patterns based on a few user seed tuples, and then extracts new tuples from the biomedical web documents based on the discovered patterns.

TL;DR: The experiments of SPIE-DM indicate that the system is very promising for extracting and mining from biomedical literature databases.

TL;DR: A mouse model for CdLS was developed, using mice heterozygous for a gene-trap mutation (Nipbl 564) that is predicted to produce a transcript that terminates before the first coding exon, suggesting upregulation of the wild-type allele.