Kyoko Yokomori

TL;DR: It is shown that the distribution of cohesins on mammalian chromosome arms is not driven by transcriptional activity, in contrast to S. cerevisiae, and recruitment by CTCF suggests a rationale for noncanonical cohesin functions and, because C TCF binding is sensitive to DNA methylation, allows cohesIn positioning to integrate DNA sequence and epigenetic state.

TL;DR: In vitro assembly and transcriptional properties of TBP-TAF complexes reconstituted from the nine recombinant subunits of Drosophila TFIID are reported and it is suggested that TAFs perform multiple functions during activation.

TL;DR: The results indicate at least two distinct steps in kinetochores assembly: precise targeting of CENP-A, which is sufficient to assemble components of a centromere-prekinetochore scaffold; and targeting of kinetchore microtubule-associated proteins by an additional mechanism present only at active centromeres.

TL;DR: It is suggested that TAFs play a critical role in promoter selectivity and transcription regulation through direct contacts with core promoter elements in directing basal promoter function.

TL;DR: The isolation of a human ISWI (SNF2h)-containing chromatin remodelling complex that encompasses components of the cohesin and NuRD complexes is reported and it is shown that the hRAD21 subunit of the Cohesin complex directly interacts with the ATPase subunit SNF2H.