M
Mark Trinder
Researcher at University of British Columbia
Publications - 57
Citations - 1462
Mark Trinder is an academic researcher from University of British Columbia. The author has contributed to research in topics: Medicine & Familial hypercholesterolemia. The author has an hindex of 16, co-authored 41 publications receiving 669 citations. Previous affiliations of Mark Trinder include University of Western Ontario & Lawson Health Research Institute.
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Journal ArticleDOI
Association of Monogenic vs Polygenic Hypercholesterolemia With Risk of Atherosclerotic Cardiovascular Disease.
TL;DR: This cohort study uses the UK Biobank cohort data to compare the association of monogenic vs polygenic hypercholesterolemia with the risk of atherosclerotic cardiovascular disease among individuals with comparable levels of low-density lipoprotein cholesterol.
Journal ArticleDOI
Risk of Premature Atherosclerotic Disease in Patients With Monogenic Versus Polygenic Familial Hypercholesterolemia
Mark Trinder,Xuan Li,Maria Liza DeCastro,Luba Cermakova,Singh N. Sadananda,Linda M. Jackson,Hawmid Azizi,G.B. John Mancini,Gordon A. Francis,Jiri Frohlich,Liam R. Brunham +10 more
TL;DR: Patients with monogenic FH and superimposed elevated LDL-C polygenic risk scores have the greatest risk of premature CVD.
Journal ArticleDOI
Clinical Utility of Lipoprotein(a) and LPA Genetic Risk Score in Risk Prediction of Incident Atherosclerotic Cardiovascular Disease
Mark Trinder,Mark Trinder,Mesbah Uddin,Phoebe Finneran,Phoebe Finneran,Krishna G. Aragam,Pradeep Natarajan +6 more
TL;DR: Both measured lipoprotein(a) and LPA GRS were associated with comparable risk of incident ASCVD events and both yielded modest improvements in the discrimination of ASCVD risk relative to the Pooled Cohort Equations or QRISK3.
Journal ArticleDOI
Distinction of lymphoid and myeloid clonal hematopoiesis
Abhishek Niroula,Abhishek Niroula,Abhishek Niroula,Aswin Sekar,Mark A. Murakami,Mark Trinder,Mark Trinder,Mridul Agrawal,Waihay J. Wong,Waihay J. Wong,Alexander G. Bick,Alexander G. Bick,Mesbah Uddin,Mesbah Uddin,Christopher J. Gibson,Christopher J. Gibson,Gabriel K. Griffin,Gabriel K. Griffin,Michael C. Honigberg,Michael C. Honigberg,Seyedeh M. Zekavat,Seyedeh M. Zekavat,Kaavya Paruchuri,Pradeep Natarajan,Pradeep Natarajan,Benjamin L. Ebert,Benjamin L. Ebert,Benjamin L. Ebert +27 more
TL;DR: In this article, the authors performed an integrated analysis of gene mutations associated with hematologic malignancies detected in hematopoietic cells of healthy individuals, referred to as CH of indeterminate potential (CHIP), and found that myeloid and lymphoid gene mutations were associated with risk of lineage-specific malignancy.
Journal ArticleDOI
Neonicotinoid-induced pathogen susceptibility is mitigated by Lactobacillus plantarum immune stimulation in a Drosophila melanogaster model.
Brendan A. Daisley,Brendan A. Daisley,Mark Trinder,Mark Trinder,Tim McDowell,Hylke Welle,Hylke Welle,Hylke Welle,Josh S. Dube,Sohrab Naushad Ali,Sohrab Naushad Ali,Hon S. Leong,Mark W. Sumarah,Gregor Reid,Gregor Reid +14 more
TL;DR: The results suggested that the immune deficiency (Imd) pathway is necessary for D. melanogaster survival in response to IMI toxicity and potential for probiotic lactobacilli to reduce IMI-induced susceptibility to infection.