M
Markku Koulu
Researcher at University of Turku
Publications - 106
Citations - 4827
Markku Koulu is an academic researcher from University of Turku. The author has contributed to research in topics: Neuropeptide Y receptor & Agonist. The author has an hindex of 37, co-authored 106 publications receiving 4674 citations. Previous affiliations of Markku Koulu include University of Oulu.
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Journal ArticleDOI
Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy
TL;DR: The extracellular matrix (ECM) consists of numerous macromolecules classified traditionally into collagens, elastin, and microfibrillar proteins, proteoglycans including hyaluronan, and noncollagenous glycoproteins, and this activity may in part be beneficial to the drugs' disease-modifying properties.
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Inverse Correlation between Serum Testosterone and Leptin in Men
Virve Luukkaa,Ullamari Pesonen,Ilpo Huhtaniemi,Aapo Lehtonen,Reijo S. Tilvis,Jaakko Tuomilehto,Markku Koulu,Risto Huupponen +7 more
TL;DR: It is concluded that testosterone has a suppressive effect on leptin production, as reflected by circulating levels of this hormone in elderly men.
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Effects of dexmedetomidine, a selective α2‐adrenoceptor agonist, on hemodynamic control mechanisms
Antero Kallio,Antero Kallio,Mika Scheinin,Mika Scheinin,Markku Koulu,Markku Koulu,Riitta Ponkilainen,Riitta Ponkilainen,Heikki Ruskoaho,Heikki Ruskoaho,Osmo Viinamäki,Osmo Viinamäki,Harry Scheinin,Harry Scheinin +13 more
TL;DR: Dexmedetomidine is a potentially useful tool for studies of the physiology and pharmacology of α2‐adrenoceptors in human beings and may have therapeutic applications in clinical conditions in which sedative and sympatholytic effects are considered beneficial, such as premedication for anesthesia and surgery.
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Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels
Matti K. Karvonen,Ullamari Pesonen,Markku Koulu,Leo Niskanen,Markku Laakso,Aila Rissanen,Jacqueline M. Dekker,Leen M 't Hart,Raisa Valve,Matti Uusitupa +9 more
TL;DR: Evidence is provided that NPY is linked to cholesterol metabolism and that the polymorphism producing Pro(7) inNPY is one of the strongest genetic factors identified thus far affecting serum cholesterol, particularly in obese subjects.
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Association Between the Functional Variant of the catechol-O-methyltransferase (COMT) Gene and Type 1 Alcoholism
Jari Tiihonen,Tero Hallikainen,Herbert M. Lachman,Takuya Saito,Jan Volavka,Jussi Kauhanen,Jukka T. Salonen,Olli-Pekka Ryynänen,Markku Koulu,Matti K. Karvonen,Tiina Pohjalainen,Erkka Syvälahti,Jarmo Hietala +12 more
TL;DR: The results indicate that the COMT polymorphism contributes significantly to the development of late-onset alcoholism.