Marko Klobučar

TL;DR: Results of anti-proliferative assays performed on a panel of selected human tumor cell lines revealed that compound 6 had moderate cytostatic activity against the HeLa cell line, whereas compound 10 showed moderate activity againstthe HeLa, HepG2 and SW620 cell lines.

TL;DR: Several novel 6-substituted-2-arylbenzothiazole compounds were revealed, with strong and selective antiproliferative activity towards HeLa cells in micro and submicromolar concentrations, with the most selective compounds being 6-ammonium-2-(2-hydroxy/methoxyphenyl)benZothiazoles 5f and 6f.

TL;DR: In this paper, the authors performed quantitative proteomic profiling of patient-matched primary tumor and adjacent non-tumorous tissues derived from metastatic laryngeal squamous cell carcinoma (LSCC) to identify new protein candidates with potential diagnostic and therapeutic significance.

TL;DR: Analysis showed that compound 8m strongly enhanced expression of hypoxia inducible transcription factor 1 α and to some extent decreased expression of nitric oxide synthase 2 (NOS2) suggesting its role in regulating HIF-1α signalling pathway.

TL;DR: Investigation of the anticancer efficacy and underlying molecular mechanisms of combined administration of 5-FU and dual Sphk1/Sphk2 inhibitor SKI-II in HepG2 hepatocellular carcinoma cells show that pharmacological blockade of both Sphk isoforms represents a promising strategy to boost the anti-tumour efficacy of5-FU.