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Markus Seiler
Researcher at European Bioinformatics Institute
Publications - 11
Citations - 1650
Markus Seiler is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: Short linear motif & Eukaryotic Linear Motif resource. The author has an hindex of 10, co-authored 10 publications receiving 1483 citations. Previous affiliations of Markus Seiler include German Cancer Research Center.
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Journal ArticleDOI
ELM—the database of eukaryotic linear motifs
Holger Dinkel,Sushama Michael,Robert J. Weatheritt,Norman E. Davey,Kim Van Roey,Brigitte Altenberg,Grischa Toedt,Bora Uyar,Markus Seiler,Aidan Budd,Lisa Jödicke,Marcel Andre Dammert,Christian Schroeter,Maria Hammer,Tobias Schmidt,Peter Jehl,Caroline McGuigan,Magdalena Dymecka,Claudia Chica,Katja Luck,Allegra Via,Andrew Chatr-aryamontri,Niall J. Haslam,Gleb Grebnev,Richard Edwards,Michel O. Steinmetz,Heike Meiselbach,Francesca Diella,Toby J. Gibson +28 more
TL;DR: The motif discovery portion of the ELM resource has added conservation, and structural attributes have been incorporated to aid users to discriminate biologically relevant motifs from stochastically occurring non-functional instances.
Journal ArticleDOI
Short linear motifs: ubiquitous and functionally diverse protein interaction modules directing cell regulation.
Kim Van Roey,Bora Uyar,Robert J. Weatheritt,Holger Dinkel,Markus Seiler,Aidan Budd,Toby J. Gibson,Norman E. Davey,Norman E. Davey +8 more
TL;DR: Interaction Modules Directing Cell Regulation Kim Van Roey, Bora Uyar,† Robert J. Weatheritt,‡ Holger Dinkel,† Markus Seiler,† Aidan Budd,† Toby J. Gibson,† and Norman E. Davey*.
Journal ArticleDOI
The eukaryotic linear motif resource ELM: 10 years and counting
Holger Dinkel,Kim Van Roey,Sushama Michael,Norman E. Davey,Robert J. Weatheritt,Diana Born,Tobias Speck,Daniel Krüger,Gleb Grebnev,Marta Kubań,Marta Strumillo,Bora Uyar,Aidan Budd,Brigitte Altenberg,Markus Seiler,Lucía B. Chemes,Lucía B. Chemes,Juliana Glavina,Ignacio E. Sánchez,Francesca Diella,Toby J. Gibson +20 more
TL;DR: The eukaryotic linear motif (ELM) resource is a hub for collecting, classifying and curating information about short linear motifs (SLiMs) and detailed information about motif-mediated interactions has been annotated and made available in standard exchange formats.
Journal ArticleDOI
ELM: the status of the 2010 eukaryotic linear motif resource
Cathryn M. Gould,Francesca Diella,Allegra Via,Pål Puntervoll,Christine Gemünd,Sophie Chabanis-Davidson,Sushama Michael,Ahmed Sayadi,Jan Christian Bryne,Claudia Chica,Markus Seiler,Norman E. Davey,Neill Haslam,Robert J. Weatheritt,Aidan Budd,Timothy P. Hughes,Jakub Pas,Leszek Rychlewski,Gilles Travé,Rein Aasland,Manuela Helmer-Citterich,Rune Linding,Toby J. Gibson +22 more
TL;DR: The ELM resource at http://elm.eu provides an expanding knowledge base, currently covering 146 known motifs, with annotation that includes >1300 experimentally reported instances, and is an exploratory tool for suggesting new candidates of known linear motifs in proteins of interest.
Journal ArticleDOI
The transience of transient overexpression
TL;DR: Much of what is known about mammalian cell regulation has been achieved with the aid of transiently transfected cells, but genome engineering technologies now enable the generation of stable cell lines expressing modified proteins at (almost) native levels.