Marta González-Bártulos

TL;DR: The low toxicity and the excellent cell-penetrating properties of BP16 clearly suggest that BP16 is a suitable vector for the delivery of therapeutic agents into cells.

TL;DR: The cytotoxic activity trends are explained in terms of the higher reactivity of derivatives from series b, which is rationalized as being the result of the electronic features of dpim and PPh(2)py established by cyclic voltammetry measurements.

TL;DR: It is reported that, upon chelation of intracellular iron, the pro-oxidant activity of amine-pyrimidine-based iron complexes efficiently kills cancer and cancer stem-like cells, thus providing functional evidence for an efficient family of redox-directed anti-cancer metallodrugs.

TL;DR: Additional binding assays and mechanistic studies demonstrate that the enhanced cleavage activities are explained by the presence of the cationic LKKL tetrapeptide sequence, which induces an improved binding affinity to the DNA, thus bringing the metal ion, which is responsible for cleavage, in close proximity.

TL;DR: The combination of BP16 with an enzymatic cleavable sequence can be used as a drug delivery system for the effective uptake and release of drugs in cancer cells.