M
Marta S. De Freitas
Researcher at Rio de Janeiro State University
Publications - 30
Citations - 1510
Marta S. De Freitas is an academic researcher from Rio de Janeiro State University. The author has contributed to research in topics: Chemotaxis & Integrin. The author has an hindex of 22, co-authored 30 publications receiving 1434 citations. Previous affiliations of Marta S. De Freitas include University of São Paulo.
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Journal ArticleDOI
Neutrophil activation by heme: implications for inflammatory processes.
Aurélio V. Graça-Souza,Maria Augusta Arruda,Marta S. De Freitas,Christina Barja-Fidalgo,Pedro L. Oliveira +4 more
TL;DR: A role for hemin as a proinflammatory agent able to induce polymorphonuclear neutrophil activation in situations of clinical relevance, such as hemolysis or hemoglobinemia is suggested.
Journal ArticleDOI
Impaired neutrophil chemotaxis in sepsis associates with GRK expression and inhibition of actin assembly and tyrosine phosphorylation
Sandra Mara A. Arraes,Sandra Mara A. Arraes,Marta S. De Freitas,Marta S. De Freitas,Simone V. da Silva,Simone V. da Silva,Heitor A. Paula Neto,Heitor A. Paula Neto,José C. Alves-Filho,José C. Alves-Filho,Maria Auxiliadora Martins,Maria Auxiliadora Martins,Anibal Basile-Filho,Anibal Basile-Filho,Beatriz Martins Tavares-Murta,Beatriz Martins Tavares-Murta,Christina Barja-Fidalgo,Christina Barja-Fidalgo,Fernando Q. Cunha,Fernando Q. Cunha +19 more
TL;DR: Data suggest that endogenous mediators produced during sepsis might continually activate circulating neutrophils, leading to GRK activation, which may induce neutrophil desensitization to chemoattractants.
Journal ArticleDOI
Heme Inhibits Human Neutrophil Apoptosis: Involvement of Phosphoinositide 3-Kinase, MAPK, and NF-κB
Maria Augusta Arruda,Adriano G. Rossi,Marta S. De Freitas,Christina Barja-Fidalgo,Aurélio V. Graça-Souza +4 more
TL;DR: It is shown that heme (1–50 μM) delays human neutrophil spontaneous apoptosis in vitro, and the involvement of the Ras/Raf/MAPK and PI3K pathway and ERK-2 nuclear translocation pathways in the modulation of the antiapoptotic effect is confirmed.
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Phosphoinositide-3 kinases critically regulate the recruitment and survival of eosinophils in vivo: importance for the resolution of allergic inflammation.
Vanessa Pinho,Danielle G. Souza,Michele M. Barsante,Fabiana P. Hamer,Marta S. De Freitas,Adriano G. Rossi,Mauro M. Teixeira +6 more
TL;DR: An important role of PI3Kγ for the maintenance of eosinophilic inflammation in vivo is demonstrated, whereas other isoforms ofPI3K may be relevant for the recruitment process.
Journal ArticleDOI
Clotrimazole decreases human breast cancer cells viability through alterations in cytoskeleton-associated glycolytic enzymes.
Débora Dummer Meira,Monica M. Marinho-Carvalho,Cesar Augusto Antunes Teixeira,Venicio Feo da Veiga,Andrea T. Da Poian,Carla Holandino,Marta S. De Freitas,Mauro Sola-Penna +7 more
TL;DR: Evidence for apoptotic events that might be started by clotrimazole involving inhibition of glycolytic flux in MCF-7 cells is supported and makes this drug a promising agent in the fight against human breast cancer.